Application of arene-ruthenium chemistry to a formal total synthesis of OF 4949 III

被引：50

作者：

Pearson, AJ

Zhang, PL

Lee, K

机构：

[1] Department of Chemistry, Case Western Reserve University, Cleveland

来源：

JOURNAL OF ORGANIC CHEMISTRY | 1996年 / 61卷 / 19期

关键词：

D O I：

10.1021/jo960956l

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A convergent formal total synthesis of OF 4949 III is described. Arene-ruthenium chemistry was used in the construction of the diaryl ether linkage in high yield, and cycloamidation under high dilution conditions (0.005 M) was achieved using DPPA as coupling reagent. SmI2 was used to reductively remove the 2-iodoethyl ester protecting group in the presence of DMPU or HMPA.

引用

页码：6581 / 6586

页数：6

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