Structural and biophysical insight into cholesteryl ester-transfer protein

被引：11
|
作者：
Hall, Justin [1 ]
Qiu, Xiayang [1 ]
机构：
[1] Pfizer Res & Dev, Groton, CT 06430 USA
来源：
BIOCHEMICAL SOCIETY TRANSACTIONS | 2011年 / 39卷
关键词：
cardiovascular disease (CVD); cholesteryl ester-transfer protein (CETP); neutral lipid; phospholipid; triacylglycerol (TAG); CORONARY-HEART-DISEASE; HIGH-DENSITY-LIPOPROTEINS; APOLIPOPROTEIN-A-I; NEUTRALIZING MONOCLONAL-ANTIBODY; PERMEABILITY-INCREASING PROTEIN; INTIMA-MEDIA THICKNESS; HUMAN-PLASMA; CRYSTAL-STRUCTURE; CARDIOVASCULAR-DISEASE; THERAPEUTIC TARGET;
D O I：
10.1042/BST0391000
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
CETP (cholesteryl ester-transfer protein) is essential for neutral lipid transfer between HDL (high-density lipoprotein) and LDL (low-density lipoprotein) and plays a critical role in the reverse cholesterol transfer pathway. In clinical trials, CETP inhibitors increase HDL levels and reduce LDL levels, and therefore may be used as a potential treatment for atherosclerosis. In this review, we cover the analysis of CETP structure and provide insights into CETP-mediated lipid transfer based on a collection of structural and biophysical data.
引用
收藏
页码：1000 / 1005
页数：6
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