Salvia miltiorrhiza Protects Endothelial Dysfunction against Mitochondrial Oxidative Stress

被引：14
|
作者：
Cheng, Yu-Chen [1 ,2 ]
Hung, I-Ling [1 ,2 ]
Liao, Yen-Nung [1 ,2 ,3 ]
Hu, Wen-Long [1 ,2 ,4 ,5 ]
Hung, Yu-Chiang [1 ,2 ]
机构：
[1] Kaohsiung Chang Gung Mem Hosp, Dept Chinese Med, Kaohsiung 83342, Taiwan
[2] Chang Gung Univ, Coll Med, Grad Inst Clin Med Sci, Kaohsiung 83342, Taiwan
[3] Chang Gung Univ, Grad Inst Clin Med Sci, Coll Med, Kaohsiung 33302, Taiwan
[4] Kaohsiung Med Univ, Coll Med, Kaohsiung 80708, Taiwan
[5] Fooyin Univ, Coll Nursing, Kaohsiung 83102, Taiwan
来源：
LIFE-BASEL | 2021年 / 11卷 / 11期
关键词：
Salvia miltiorrhiza; mitochondria; endothelial dysfunction; oxidative stress; TCM; herbal medicine; reactive oxygen species; cardiovascular disease; RAT CORONARY-ARTERY; ANGIOTENSIN-II; TANSHINONE IIA; NITRIC-OXIDE; ACID-B; SUPEROXIDE DISMUTASES; PROGENITOR CELLS; INFLAMMATION; INHIBITION; CALCIUM;
D O I：
10.3390/life11111257
中图分类号：
Q [生物科学];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
Salvia miltiorrhiza (SM) is a common traditional Chinese medicine used in the treatment of cardiovascular and cerebrovascular diseases. Endothelial dysfunction plays an important role in the pathology of cardiovascular diseases. Endothelial dysfunction may induce inflammation and change vascular tone and permeability. The main pathological mechanism of endothelial dysfunction is the formation of reactive oxygen species (ROS). Mitochondria are the main source of energy and can also produce large amounts of ROS. Recent studies have shown that extracts of SM have antioxidative, anti-inflammatory, and antithrombus properties. In this review, we discuss the mechanism of oxidative stress in the mitochondria, endothelial dysfunction, and the role of SM in these oxidative events.
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页数：13
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