The chemistry and biological activity of heterocycle-fused quinolinone derivatives: A review

被引：128

作者：

Shiro, Tomoya ^{[1
]}

Fukaya, Takayuki ^{[1
]}

Tobe, Masanori ^{[1
]}

机构：

[1] Sumitomo Dainippon Pharma Co Ltd, Drug Res Div, Suita, Osaka 5640053, Japan

来源：

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY | 2015年 / 97卷

关键词：

Quinolinone; Quinolin-4-one; Heterocycles; MUSCARINIC ACETYLCHOLINE-RECEPTORS; PROSTAGLANDIN E-2 SYNTHASE; PEPTIDASE-IV INHIBITOR; POSITIVE ALLOSTERIC MODULATOR; GLUCAGON-LIKE PEPTIDE-1; HIGHLY POTENT; MICE LACKING; DISCOVERY; HEDGEHOG; AMPA;

D O I：

10.1016/j.ejmech.2014.12.004

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Among all heterocycles, the heterocycle-fused quinolinone scaffold is one of the privileged structures in drug discovery as heterocycle-fused quinolinone derivatives exhibit various biological activities allowing them to act as anti-inflammatory, anticancer, antidiabetic, and antipsychotic agents. This wide spectrum of biological activity has attracted a great deal of attention in the field of medicinal chemistry. In this review, we provide a comprehensive description of the biological and pharmacological properties of various heterocycle-fused quinolinone scaffolds and discuss the synthetic methods of some of their derivatives. (C) 2014 Elsevier Masson SAS. All rights reserved.

引用

页码：397 / 408

页数：12

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