The chemistry and biological activity of heterocycle-fused quinolinone derivatives: A review

被引：128
|
作者：
Shiro, Tomoya [1 ]
Fukaya, Takayuki [1 ]
Tobe, Masanori [1 ]
机构：
[1] Sumitomo Dainippon Pharma Co Ltd, Drug Res Div, Suita, Osaka 5640053, Japan
来源：
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY | 2015年 / 97卷
关键词：
Quinolinone; Quinolin-4-one; Heterocycles; MUSCARINIC ACETYLCHOLINE-RECEPTORS; PROSTAGLANDIN E-2 SYNTHASE; PEPTIDASE-IV INHIBITOR; POSITIVE ALLOSTERIC MODULATOR; GLUCAGON-LIKE PEPTIDE-1; HIGHLY POTENT; MICE LACKING; DISCOVERY; HEDGEHOG; AMPA;
D O I：
10.1016/j.ejmech.2014.12.004
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Among all heterocycles, the heterocycle-fused quinolinone scaffold is one of the privileged structures in drug discovery as heterocycle-fused quinolinone derivatives exhibit various biological activities allowing them to act as anti-inflammatory, anticancer, antidiabetic, and antipsychotic agents. This wide spectrum of biological activity has attracted a great deal of attention in the field of medicinal chemistry. In this review, we provide a comprehensive description of the biological and pharmacological properties of various heterocycle-fused quinolinone scaffolds and discuss the synthetic methods of some of their derivatives. (C) 2014 Elsevier Masson SAS. All rights reserved.
引用
收藏
页码：397 / 408
页数：12
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