Synthesis of 1,1A′-[methylenebis(oxy)]bis[3-alkyl-3-(2-haloethyl)triaz-1-ene 2-oxides]

被引：9

作者：

Pokhvisneva, G. V. ^{[1
]}

Ternikova, T. V. ^{[1
]}

Smirnov, G. A. ^{[1
]}

Gordeev, P. B. ^{[1
]}

Nikitin, S. V. ^{[1
]}

Luk 'yanov, O. A. ^{[1
]}

机构：

[1] Russian Acad Sci, ND Zelinsky Inst Organ Chem, 47 Leninsky Prosp, Moscow 119991, Russia

来源：

RUSSIAN CHEMICAL BULLETIN | 2017年 / 66卷 / 07期

基金：

俄罗斯科学基金会;

关键词：

1,1 '-[methylenebis(oxy)]bis[3-alkyl-3-(2-haloethyl)triaz-1-ene 2-oxides; 1,1 '-[methylenebis(oxy)]bis[3-alkyl-3-(2-hydroxyethyl)triaz-1-ene 2-oxides; alkylation; chlorination; bromination; iodination; METHYLENE-BIS(1-OXY-3,3-DIALKYL-1-TRIAZENE 2-OXIDES); DERIVATIVES; SYSTEMS;

D O I：

10.1007/s11172-017-1878-5

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A method for the synthesis of promising nitric oxide donors in living organisms, 1,1A '-[methylenebis(oxy)]bis[3-alkyl-3-(2-haloethyl)triaz-1-ene 2-oxides] was elaborated. The method involved replacement of hydroxy groups of the corresponding 1,1A '-[methylenebis(oxy)]bis[3-alkyl-3-(2-hydroxyethyl)triaz-1-ene 2-oxides] by halogen atoms and, in some cases, the exchange of one halogen atom for another.

引用

页码：1234 / 1239

页数：6

共 50 条

[1] Synthesis of 1,1´-[methylenebis(oxy)]bis[3-alkyl-3-(2-haloethyl)triaz-1-ene 2-oxides]
G. V. Pokhvisneva
T. V. Ternikova
G. A. Smirnov
P. B. Gordeev
S. V. Nikitin
O. A. Luk´yanov
Russian Chemical Bulletin, 2017, 66 : 1234 - 1239
[2] Synthesis of 1,1'-[methylenebis(oxy)]-bis[3-alkyl-3-(2-hydroxyethyl)triaz-1-ene 2-oxides]
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[3] Synthesis of 1,1’-[methylenebis(oxy)]-bis[3-alkyl-3-(2-hydroxyethyl)triaz-1-ene 2-oxides]
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Russian Chemical Bulletin, 2016, 65 : 2650 - 2657
[4] Synthesis of 3,3-bis(2-haloethyl) and 3,3,3′-tris(2-haloethyl) derivatives of 1,1′-[methylenebis(oxy)]bis(triaz-1-ene 2-oxides)
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Russian Chemical Bulletin, 2017, 66 : 2103 - 2109
[5] Synthesis of 3,3-bis(2-haloethyl) and 3,3,3'-tris(2-haloethyl) derivatives of 1,1'-[methylenebis(oxy)]bis(triaz-1-ene 2-oxides)
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[6] N--Nitroxyethyl derivatives of 1,1'-[methylenebis(oxy)]bis(triaz-1-ene 2-oxides)
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[7] N-β-Nitroxyethyl derivatives of 1,1’-[methylenebis(oxy)]bis(triaz-1-ene 2-oxides)
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[8] 3,3-Bis(2-nitroxyethyl) derivatives of 1,1′-[methylenebis(oxy)]bis(triaz-1-ene 2-oxides) as a new type of NO donors
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[9] 3,3-Bis(2-nitroxyethyl) derivatives of 1,1′-[methylenebis(oxy)]bis(triaz-1-ene 2-oxides) as a new type of NO donors
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[10] Synthesis of 3,3-bis(2-hydroxyethyl) and 3,3,3’-tris(2-hydroxyethyl) derivatives of 1,1’-[methylenebis(oxy)]bis(triaz-1-ene 2-oxides)
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G. V. Pokhvisneva
G. A. Smirnov
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