N-Amino-imidazol-2-one (Nai) Residues as Tools for Peptide Mimicry: Synthesis, Conformational Analysis and Biomedical Applications

被引：1

作者：

Hamdane, Yousra ^{[1
]}

Poupart, Julien ^{[1
]}

Lubell, William D. ^{[1
]}

机构：

[1] Univ Montreal, Dept Chim, Succursale Ctr Ville, Montreal, PQ H3C 3J7, Canada

来源：

SYNTHESIS-STUTTGART | 2022年 / 54卷 / 06期

基金：

加拿大自然科学与工程研究理事会;

关键词：

N; -aminoimidazol-2-one; Nai residue; peptide mimicry; 5-endo-dig cyclization; beta-turn; organocatalysis; cluster of differentiation-36 (CD36); ASYMMETRIC ALPHA-AMINATION; AMINO-ACIDS; DESIGN; AZOPEPTIDES; ANALOGS; CLUSTER;

D O I：

10.1055/s-0040-1719862

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

N-Amino-imidazol-2-one (Nai) residues are tools for studying peptide-backbone and side-chain conformation and function. Recent methods for substituted Nai residue synthesis, conformational analysis by X-ray crystallography and computation, and biomedical applications are reviewed, demonstrating the utility of this constrained residue to favor biologically active turn conformers with defined.-dihedral angle orientations. 1 Introduction 2 Synthetic Methods 3 Conformational Analysis 4 Biomedical Applications 5 Conclusions

引用

页码：1518 / 1526

页数：9

共 29 条

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