A one-pot radioiodination of aryl amines via stable diazonium salts: preparation of 125I-imaging agents

被引：25
|
作者：
Sloan, Nikki L. [1 ]
Luthra, Sajinder K. [2 ]
McRobbie, Graeme [2 ]
Pimlott, Sally L. [3 ]
Sutherland, Andrew [1 ]
机构：
[1] Univ Glasgow, Sch Chem, WestCHEM, Joseph Black Bldg, Glasgow G12 8QQ, Lanark, Scotland
[2] GE Healthcare, Grove Ctr, White Lion Rd, Amersham HP7 9LL, England
[3] Greater Glasgow & Clyde NHS Trust, West Scotland PET Ctr, Glasgow G12 0YN, Lanark, Scotland
来源：
CHEMICAL COMMUNICATIONS | 2017年 / 53卷 / 80期
关键词：
BENZODIAZEPINE-RECEPTOR; RADIOSYNTHESIS; IODINATION; I-123; RADIOLIGAND; TRACERS; ARENES;
D O I：
10.1039/c7cc06211g
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
An operationally simple, one-pot, two-step tandem procedure that allows the incorporation of radioactive iodine into aryl amines via stable diazonium salts is described. The mild conditions are tolerant of various functional groups and substitution patterns, allowing latestage, rapid access to a wide range of I-125-labelled aryl compounds and SPECT radiotracers.
引用
收藏
页码：11008 / 11011
页数：4
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