APOE E2/E2 Is Associated with Slower Rate of Cognitive Decline with Age

被引:8
|
作者
Sweigart, Benjamin [1 ]
Andersen, Stacy L. [2 ]
Gurinovich, Anastasia [3 ]
Cosentino, Stephanie [4 ,5 ,6 ]
Schupf, Nicole [4 ,5 ,6 ]
Perls, Thomas T. [2 ]
Sebastiani, Paola [3 ]
机构
[1] Boston Univ, Dept Biostat, Sch Publ Hlth, 801 Massachusetts Ave 3rd Floor, Boston, MA 02118 USA
[2] Boston Univ, Dept Med, Geriatr Sect, Sch Med, Boston, MA 02118 USA
[3] Tufts Med Ctr, Inst Clin Res & Hlth Policy Studies, Boston, MA 02111 USA
[4] Columbia Univ, Dept Neurol, Cognit Neurosci Div, New York, NY USA
[5] Columbia Univ, Taub Inst Res Alzheimers Dis & Aging Brain, New York, NY USA
[6] Columbia Univ, Gertrude H Sergievsky Ctr, New York, NY 10027 USA
关键词
Apolipoproteins E; cognitive aging; cognitive dysfunction; genetics; APOLIPOPROTEIN-E; ALZHEIMERS-DISEASE; FOLLOW-UP; GENOTYPE; LIFE; LONGEVITY; EPSILON-4; DEMENTIA; ALLELE; FAMILY;
D O I
10.3233/JAD-201205
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Background: The E4 allele of the APOE gene is known to be associated with cognitive impairment. However, a limited number of studies have examined the association between the E2 allele and longitudinal changes of cognitive function. Objective: To determine whether rates of cognitive change differ in carriers of the APOE E2 allele compared to other genotypes. Methods: We conducted a secondary analysis of data from two ongoing longitudinal cohort studies, the Long Life Family Study (LLFS) and New England Centenarian Study (NECS). We included participants who had APOE genotyping data, data from longitudinal administrations of the Telephone Interview for Cognitive Status (TICS), and age, sex, and education available. We assessed whether cognitive change as measured by rate of decline in TICS score differed among people with different APOE genotypes. We used a hierarchical mixed effect model with APOE genotypes, their interactions with age, and potential confounders. Results: After adjusting for sex and education, in carriers of the common E3/E3 genotype, TICS score decreased by 0.15 points per year of age. In those with the E2/E2 genotype, TICS score decreased by 0.05 points per year of age, a significantly slower rate of decline (p = 0.017). We observed no protective effect of the E2/E3 genotype on cognitive decline. Conclusion: These results suggest a protective effect of the E2/E2 genotype on a measure of global cognitive function.
引用
收藏
页码:853 / 860
页数:8
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