Photostability Study of Doxorubicin Aqueous Solution Enhanced by Inclusion Interaction between Doxorubicin and Hydroxypropyl-β-cyclodextrin

被引：12
|
作者：
Peng Mingli [1 ]
Liu Yanhong [2 ]
Zhang Hua [2 ]
Cui Yali [2 ]
Zhai Gaohong [1 ]
Chen Chao [2 ]
机构：
[1] NW Univ Xian, Coll Chem & Mat Sci, Minist Educ, Key Lab Synthet & Nat Funct Mol Chem, Xian 710069, Shaanxi, Peoples R China
[2] Natl Engn Res Ctr Miniaturized Detect Syst, Xian 710069, Shaanxi, Peoples R China
来源：
CHINESE JOURNAL OF CHEMISTRY | 2010年 / 28卷 / 07期
关键词：
hydroxypropyl-beta-cyclodextrin; doxorubicin; inclusion complex; photostability; molecular modeling; COMPLEXES; RELEASE; HYDROCHLORIDE;
D O I：
10.1002/cjoc.201090223
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
The photodegradation of doxorubicin (Dox) in the presence of hydroxypropyl-beta-cyclodextrin (HP-beta-CD) was studied; the degradation rate constant in the presence of HP-beta-CD estimated by Lineweaver-Burk analysis was approximately three times lower than that of free Dox aqueous solution, which shows that HP-beta-CD can enhance the photostability of doxorubicin aqueous solution. The enhancement may be attributed to the inclusion interaction between HP-beta-CD and doxorubicin. The characterization of FTIR, DSC, XRD and fluorescence titration indicates that 1 : 1 inclusion complex is formed between HP-beta-CD and doxorubicin.
引用
收藏
页码：1291 / 1295
页数：5
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