Photostability Study of Doxorubicin Aqueous Solution Enhanced by Inclusion Interaction between Doxorubicin and Hydroxypropyl-β-cyclodextrin

被引：12

作者：

Peng Mingli ^{[1
]}

Liu Yanhong ^{[2
]}

Zhang Hua ^{[2
]}

Cui Yali ^{[2
]}

Zhai Gaohong ^{[1
]}

Chen Chao ^{[2
]}

机构：

[1] NW Univ Xian, Coll Chem & Mat Sci, Minist Educ, Key Lab Synthet & Nat Funct Mol Chem, Xian 710069, Shaanxi, Peoples R China

[2] Natl Engn Res Ctr Miniaturized Detect Syst, Xian 710069, Shaanxi, Peoples R China

来源：

CHINESE JOURNAL OF CHEMISTRY | 2010年 / 28卷 / 07期

关键词：

hydroxypropyl-beta-cyclodextrin; doxorubicin; inclusion complex; photostability; molecular modeling; COMPLEXES; RELEASE; HYDROCHLORIDE;

D O I：

10.1002/cjoc.201090223

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The photodegradation of doxorubicin (Dox) in the presence of hydroxypropyl-beta-cyclodextrin (HP-beta-CD) was studied; the degradation rate constant in the presence of HP-beta-CD estimated by Lineweaver-Burk analysis was approximately three times lower than that of free Dox aqueous solution, which shows that HP-beta-CD can enhance the photostability of doxorubicin aqueous solution. The enhancement may be attributed to the inclusion interaction between HP-beta-CD and doxorubicin. The characterization of FTIR, DSC, XRD and fluorescence titration indicates that 1 : 1 inclusion complex is formed between HP-beta-CD and doxorubicin.

引用

页码：1291 / 1295

页数：5

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