18-methoxycoronardine attenuates nicotine-induced dopamine release and nicotine preferences in rats

被引：28
|
作者：
Glick, SD [1 ]
Maisonneuve, IM
Visker, KE
Fritz, KA
Bandarage, UK
Kuehne, ME
机构：
[1] Albany Med Coll, Dept Pharmacol & Neurosci, Albany, NY 12208 USA
[2] Univ Vermont, Dept Chem, Burlington, VT 05405 USA
来源：
PSYCHOPHARMACOLOGY | 1998年 / 139卷 / 03期
关键词：
nicotine; ibogaine; 18-methoxycoronaridine; in vivo microdialysis; drug self-administration; smoking;
D O I：
10.1007/s002130050716
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
Two studies were conducted to assess, in vivo, potential anti-nicotinic effects of the iboga alkaloid ibogaine and its synthetic congener 18-methoxycoronaridine (18-MC). As previously demonstrated for ibogaine, using microdialysis, pretreatment (19 h beforehand) with 18-MC (40 mg/kg, IP) significantly attenuated nicotine-induced dopamine release in the nucleus accumbens of awake and freely moving rats. In an oral model of nicotine self-administration. both ibogaine and 18-MC decreased rats' preferences for nicotine for at least 24 h. Acutely, during the first hour after administration, ibogaine depressed responding for water as well as for nicotine; however during this same time. 18-MC reduced nicotine intake without affecting responding for water. The results suggest that 18-MC might be the prototype of a new treatment for smoking.
引用
收藏
页码：274 / 280
页数：7
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