Defining the structural and functional roles of mutations in gp120 associated with the emergence of HIV-1 clinical resistance to the CCR5 antagonist vicriviroc

被引:0
|
作者
Howe, J. A. [1 ]
Murgolo, N. [1 ]
Hou, Y. [1 ]
Ba, L. [1 ]
Buontempo, P. [1 ]
Strizki, J. [1 ]
Ogert, R. [1 ]
机构
[1] Schering Plough Res Inst, Dept Biol Res Virol, Kenilworth, NJ USA
关键词
D O I
暂无
中图分类号
R51 [传染病];
学科分类号
100401 ;
摘要
引用
收藏
页码:A36 / A36
页数:1
相关论文
共 50 条
  • [31] Structures of the CCR5 N terminus and of a tyrosine-sulfated antibody with HIV-1 gp120 and CD4
    Huang, Chih-chin
    Lam, Son N.
    Acharya, Priyamvada
    Tang, Min
    Xiang, Shi-Hua
    Hussan, Syed Shahzad-ul
    Stanfield, Robyn L.
    Robinson, James
    Sodroski, Joseph
    Wilson, Ian A.
    Wyatt, Richard
    Bewley, Carole A.
    Kwong, Peter D.
    SCIENCE, 2007, 317 (5846) : 1930 - 1934
  • [32] Primary genotypic resistance of HIV-1 to CCR5 antagonists in CCR5 antagonist treatment-naive patients
    Soulie, Cathia
    Malet, Isabelle
    Lambert-Niclot, Sidonie
    Tubiana, Roland
    Thevenin, Monique
    Simon, Anne
    Murphy, Robert
    Katlama, Christine
    Calvez, Vincent
    Marcelin, Anne-Genevieve
    AIDS, 2008, 22 (16) : 2212 - 2214
  • [33] NMR structural analysis of the HIV-1 GP120 V3 - CCR5 co-receptor N-terminal interaction
    Galanakis, P. A.
    Kandias, N.
    Spyroulias, G. A.
    Sioumpara, M.
    Morikis, D.
    Rizos, A.
    Krambovitis, E.
    JOURNAL OF PEPTIDE SCIENCE, 2006, 12 : 196 - 196
  • [34] Short Communication: HIV-1 Variants That Use Mouse CCR5 Reveal Critical Interactions of gp120's V3 Crown with CCR5 Extracellular Loop 1
    Platt, Emily J.
    Durnin, James P.
    Kabat, David
    AIDS RESEARCH AND HUMAN RETROVIRUSES, 2015, 31 (10) : 992 - 998
  • [35] HIV-1 Escape from the CCR5 Antagonist Maraviroc Associated with an Altered and Less-Efficient Mechanism of gp120-CCR5 Engagement That Attenuates Macrophage Tropism
    Roche, Michael
    Jakobsen, Martin R.
    Sterjovski, Jasminka
    Ellett, Anne
    Posta, Filippo
    Lee, Benhur
    Jubb, Becky
    Westby, Mike
    Lewin, Sharon R.
    Ramsland, Paul A.
    Churchill, Melissa J.
    Gorry, Paul R.
    JOURNAL OF VIROLOGY, 2011, 85 (09) : 4330 - 4342
  • [36] CCR5 coreceptor utilization involves a highly conserved arginine residue of HIV type 1 gp120
    Wang, WK
    Dudek, T
    Zhao, YJ
    Brumblay, HG
    Essex, M
    Lee, TH
    PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1998, 95 (10) : 5740 - 5745
  • [37] An allosteric rheostat in HIV-1 gp120 reduces CCR5 stoichiometry required for membrane fusion and overcomes diverse entry limitations
    Platt, Emily J.
    Durnin, James P.
    Shinde, Ujwal
    Kabat, David
    JOURNAL OF MOLECULAR BIOLOGY, 2007, 374 (01) : 64 - 79
  • [38] Specific interaction of CCR5 amino-terminal domain peptides containing sulfotyrosines with HIV-1 envelope glycoprotein gp120
    Cormier, EG
    Persuh, M
    Thompson, DAD
    Lin, SW
    Sakmar, TP
    Olson, WC
    Dragic, T
    PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2000, 97 (11) : 5762 - 5767
  • [39] HIV-1 gp120 and chemokines activate ion channels in primary macrophages through CCR5 and CXCR4 stimulation
    Liu, QH
    Williams, DA
    McManus, C
    Baribaud, F
    Doms, RW
    Schols, D
    De Clercq, E
    Kotlikoff, MI
    Collman, RG
    Freedman, BD
    PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2000, 97 (09) : 4832 - 4837
  • [40] Molecular modeling on human CCR5 receptors and complex with CD4 antigens and HIV-1 envelope glycoprotein gp120
    Yang, J
    Liu, CQ
    ACTA PHARMACOLOGICA SINICA, 2000, 21 (01): : 29 - 34