Defining the structural and functional roles of mutations in gp120 associated with the emergence of HIV-1 clinical resistance to the CCR5 antagonist vicriviroc

被引:0
|
作者
Howe, J. A. [1 ]
Murgolo, N. [1 ]
Hou, Y. [1 ]
Ba, L. [1 ]
Buontempo, P. [1 ]
Strizki, J. [1 ]
Ogert, R. [1 ]
机构
[1] Schering Plough Res Inst, Dept Biol Res Virol, Kenilworth, NJ USA
关键词
D O I
暂无
中图分类号
R51 [传染病];
学科分类号
100401 ;
摘要
引用
收藏
页码:A36 / A36
页数:1
相关论文
共 50 条
  • [1] A common mechanism of clinical HIV-1 resistance to the CCR5 antagonist maraviroc despite divergent resistance levels and lack of common gp120 resistance mutations
    Roche, Michael
    Salimi, Hamid
    Duncan, Renee
    Wilkinson, Brendan L.
    Chikere, Kelechi
    Moore, Miranda S.
    Webb, Nicholas E.
    Zappi, Helena
    Sterjovski, Jasminka
    Flynn, Jacqueline K.
    Ellett, Anne
    Gray, Lachlan R.
    Lee, Benhur
    Jubb, Becky
    Westby, Mike
    Ramsland, Paul A.
    Lewin, Sharon R.
    Payne, Richard J.
    Churchill, Melissa J.
    Gorry, Paul R.
    RETROVIROLOGY, 2013, 10
  • [2] A COMMON MECHANISM OF CLINICAL HIV-1 RESISTANCE TO THE CCR5 ANTAGONIST MARAVIROC DESPITE DIVERGENT RESISTANCE LEVELS AND LACK OF COMMON GP120 RESISTANCE MUTATIONS
    Roche, M.
    Salimi, H.
    Duncan, R.
    Wilkinson, B. L.
    Chikere, K.
    Moore, M. S.
    Webb, N. E.
    Zappi, H.
    Sterjovski, J.
    Flynn, J. K.
    Ellett, A.
    Gray, L. R.
    Lee, B.
    Jubb, B.
    Westby, M.
    Ramsland, P. A.
    Lewin, S. R.
    Payne, R. J.
    Churchill, M. J.
    Gorry, P. R.
    CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY, 2013, 40 : 32 - 32
  • [3] A common mechanism of clinical HIV-1 resistance to the CCR5 antagonist maraviroc despite divergent resistance levels and lack of common gp120 resistance mutations
    Michael Roche
    Hamid Salimi
    Renee Duncan
    Brendan L Wilkinson
    Kelechi Chikere
    Miranda S Moore
    Nicholas E Webb
    Helena Zappi
    Jasminka Sterjovski
    Jacqueline K Flynn
    Anne Ellett
    Lachlan R Gray
    Benhur Lee
    Becky Jubb
    Mike Westby
    Paul A Ramsland
    Sharon R Lewin
    Richard J Payne
    Melissa J Churchill
    Paul R Gorry
    Retrovirology, 10
  • [4] Structure-Function Analysis of Human Immunodeficiency Virus Type 1 gp120 Amino Acid Mutations Associated with Resistance to the CCR5 Coreceptor Antagonist Vicriviroc
    Ogert, Robert A.
    Ba, Lei
    Hou, Yan
    Buontempo, Catherine
    Qiu, Ping
    Duca, Jose
    Murgolo, Nicholas
    Buontempo, Peter
    Ralston, Robert
    Howe, John A.
    JOURNAL OF VIROLOGY, 2009, 83 (23) : 12151 - 12163
  • [5] In vivo emergence of HIV-1 resistance to the CCR5 antagonist vicriviroc:: findings from ACTG A5211
    Tsibris, A. M. N.
    Gulick, R. M.
    Su, Z.
    Hughes, M. D.
    Flexner, C.
    Wilkin, T.
    Gross, R.
    Hirsch, M.
    Skolnick, P. R.
    Coakley, E.
    Greaves, W. L.
    Kuritzkes, D. R.
    ANTIVIRAL THERAPY, 2007, 12 (05) : S15 - S15
  • [6] In vivo emergence of HIV-1 resistance to the CCR5 antagonist vicriviroc:: findings from ACTG A5211
    Tsibris, A. M. N.
    Gulick, R. M.
    Su, Z.
    Hughes, M. D.
    Flexner, C.
    Wilkin, T.
    Gross, R.
    Hirsch, M.
    Skolnick, P. R.
    Coakley, E.
    Greaves, W. L.
    Kuritzkes, D. R.
    ANTIVIRAL THERAPY, 2007, 12 : S15 - S15
  • [7] Models of HIV-1 gp120 Complexed with CXCR4 and CCR5
    Agarwal, A.
    Stein, R. A.
    Cardozo, T.
    AIDS RESEARCH AND HUMAN RETROVIRUSES, 2013, 29 (11) : A82 - A83
  • [8] Modification of the CCR5 binding site by mutations in gp120 influence drug susceptibility and viral infectivity in one subject with clinical resistance to vicriviroc
    Ogert, R. A.
    Hou, Y.
    Ba, L.
    Buontempo, C.
    Murgolo, N.
    Qiu, P.
    Duca, J.
    Strizki, J.
    Ralston, R.
    Howe, J. A.
    ANTIVIRAL THERAPY, 2009, 14 (04) : A18 - A18
  • [9] The first structure of HIV-1 gp120 with CD4 and CCR5 receptors
    Guan, Yongjun
    CELL AND BIOSCIENCE, 2019, 9 (1):
  • [10] The first structure of HIV-1 gp120 with CD4 and CCR5 receptors
    Yongjun Guan
    Cell & Bioscience, 9