Infectious risk in pediatric organ transplant recipients: Is it increased with the new immunosuppressive agents?

被引：8
|
作者：
Renoult, E
Buteau, C
Lamarre, V
Turgeon, N
Tapiero, B
机构：
[1] Univ Montreal, Hop St Justine, Dept Pediat, Div Infect Dis, Montreal, PQ H3T 1C5, Canada
[2] Univ Montreal, Hop St Justine, Dept Microbiol & Immunol, Montreal, PQ H3T 1C5, Canada
来源：
PEDIATRIC TRANSPLANTATION | 2005年 / 9卷 / 04期
关键词：
infectious risk; immunosuppressive treatment; solid organ transplantation; children;
D O I：
10.1111/j.1399-3046.2005.00325.x
中图分类号：
R72 [儿科学];
学科分类号：
100202 ;
摘要：
The risk of infection in pediatric organ transplant recipients is determined by several factors, including age, the types of organ transplanted and the immunosuppressive treatment which has dramatically changed over the past 10 yr. Little information has been reported regarding the infectious complications related to the current immunosuppressive protocols used in these children. This paper reviews (i) the immunosuppressive agents, focusing on their mechanisms of action and on the new regimens, (ii) the infections related to excessive immunosuppression and also anti-infectious properties or infectious adverse reactions associated with specific immunosuppressive agents. With the new immunosuppressive protocols, the advances in immunologic monitoring, microbiological diagnosis, anti-infectious prophylactic and preemptive treatments, strategies to minimize the risk of infection related to the immunosuppressive therapy are proposed.
引用
收藏
页码：470 / 479
页数：10
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