CHIT1 Mutations: Genetic Risk Factor for Severe Asthma With Fungal Sensitization?

被引：24

作者：

Vicencio, Alfin G. ^{[1
]}

Chupp, Geoffrey L. ^{[2
]}

Tsirilakis, Kalliope ^{[3
,4
]}

He, Xiaoxuan ^{[2
]}

Kessel, Aaron ^{[3
,4
]}

Nandalike, Kiran ^{[3
]}

Veler, Haviva ^{[3
,4
]}

Kipperman, Stacy ^{[3
,4
]}

Young, Michael C. ^{[5
]}

Goldman, David L. ^{[3
,4
]}

机构：

[1] Cohen Childrens Med Ctr New York, Div Pediat Pulmonol & Cyst Fibrosis, New Hyde Pk, NY 11040 USA

[2] Yale Ctr Asthma & Airways Dis, New Haven, CT USA

[3] Childrens Hosp Montefiore, Dept Pediat, Bronx, NY USA

[4] Albert Einstein Coll Med, Bronx, NY 10467 USA

[5] Childrens Hosp, Dept Pediat, Div Allergy & Immunol, Boston, MA 02115 USA

来源：

PEDIATRICS | 2010年 / 126卷 / 04期

基金：

美国国家卫生研究院;

关键词：

innate immunity; allergy; chitin; CHITOTRIOSIDASE; CHITINASE;

D O I：

10.1542/peds.2010-0321

中图分类号：

R72 [儿科学];

学科分类号：

100202 ;

摘要：

Fungi can exacerbate symptoms in patients with asthma. To our knowledge, genetic risk factors for fungal-associated asthma have not been described. We present here the cases of 6 children who carried the diagnosis of severe asthma with fungal sensitization, 3 of whom were treated with and responded clinically to itraconazole therapy. All 6 patients were heterozygous for a 24-base pair duplication in the CHIT1 gene, which has been associated with decreased levels of circulating chitotriosidase and susceptibility to fungal infection. Pediatrics 2010; 126:e982-e985

引用

页码：E982 / E985

页数：4

共 50 条

[21] Severe Asthma with Fungal Sensitization: A Case Report and Review of Literature
Madani, Yasser
Barlow, Andrew
Taher, Furqan
JOURNAL OF ASTHMA, 2010, 47 (01) : 2 - 6
[22] Is sensitization to Alternaria alternata a risk factor for severe asthma?: A population-based study
Neukirch, C
Henry, C
Leynaert, B
Liard, R
Bousquet, J
Neukirch, F
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 1999, 103 (04) : 709 - 711
[23] Does Itraconazole Improve Quality of Life in Severe Asthma with Fungal Sensitization?
Khazeni, Nayer
Levitt, Joseph E.
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 2009, 180 (02) : 191 - 192
[24] Basophil activation test in the diagnosis of fungal sensitization in severe asthma patients
Kuznetsov, V
Kozlova, Y.
Frolova, E.
Uchevatkina, A.
Filippova, L.
Aak, O.
Vasilyeva, N.
Klimko, N.
ALLERGY, 2020, 75 : 362 - 362
[25] Sensitization to Alternaria as a risk factor for asthma.
Perzanowski, MS
Sporik, RB
Squillace, SP
Bavbek, S
Carter, M
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 1997, 99 (01) : 1666 - 1666
[26] An exacerbation of severe asthma with fungal sensitization successfully treated with voriconazole via a reduction of the fungal burden
Katsube, Otohiro
Kono, Yuta
Tsuzuki, Ryuta
Yamawaki, Satoshi
Soeda, Seiko
To, Masako
To, Yasuo
ALLERGOLOGY INTERNATIONAL, 2019, 68 (04) : 549 - 551
[27] GENETIC POLYMORPHISMS IN CHIT1 GENE AND LEVELS OF PLASMA CHITOTRIOSIDASE AND YKL-40 IN ALCOHOL- ASSOCIATED HEPATITIS
Narayanan, Praveena
Ruan, Jiapeng
Nair, Shiny
Aerts, Johannes
Mistry, Pramod K.
HEPATOLOGY, 2023, 78 : S1604 - S1605
[28] Voriconazole and Posaconazole Improve Asthma Severity in Allergic Bronchopulmonary Aspergillosis and Severe Asthma with Fungal Sensitization
Chishimba, Livingstone
Niven, Robert M.
Cooley, John
Denning, David W.
JOURNAL OF ASTHMA, 2012, 49 (04) : 423 - 433
[29] Improvement in asthma severity and control by voriconazole and posaconazole in severe asthma with fungal sensitization (SAFS) and ABPA
Chishimba, Livingstone
Niven, Robert
Denning, David
EUROPEAN RESPIRATORY JOURNAL, 2012, 40
[30] Association of 24 bp Duplication of Human CHIT1 Gene with Asthma in a Heterozygous Population of North India: A Case–Control Study
Shweta Sinha
Jagtar Singh
Surinder Kumar Jindal
Niti Birbian
Neha Singla
Lung, 2014, 192 : 685 - 691

← 1 2 3 4 5 →