Liquid phase synthesis of chiral quinoxalinones by microwave irradiation

被引：65
|
作者：
Tung, CL [1 ]
Sun, CM [1 ]
机构：
[1] Natl Dong Hwa Univ, Lab Combinatorial Drug Discovery, Shoufeng 974, Hualien, Taiwan
来源：
TETRAHEDRON LETTERS | 2004年 / 45卷 / 06期
关键词：
D O I：
10.1016/j.tetlet.2003.12.056
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Single mode microwave-assisted combinatorial synthesis of biologically interesting quinoxalinones is described. Chiral libraries of quinoxalinone were readily assembled utilizing SNAr reactions, reduction and followed with concomitant cyclization under microwave irradiation. Enantiomeric 1,2,3,4-tetrahydroquinoxalinones were isolated in excellent yield and purity after cleavage. (C) 2003 Elsevier Ltd. All rights reserved.
引用
收藏
页码：1159 / 1162
页数：4
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