The role of lncRNAs and XIST in oral cancer

被引：9

作者：

Liu, Huimin ^{[1
]}

Wang, Dongxu ^{[2
]}

Kan, Shaoning ^{[1
]}

Hao, Ming ^{[1
]}

Chang, Lu ^{[1
]}

Lu, Pengxu ^{[2
]}

Liu, Yangyang ^{[3
]}

Jin, Ye ^{[3
]}

Liu, Weiwei ^{[1
,4
]}

机构：

[1] Jilin Univ, Hosp Stomatol, Dept Oral & Maxillofacial Surg, Changchun, Peoples R China

[2] Jilin Univ, Coll Anim Sci, Lab Anim Ctr, Changchun, Peoples R China

[3] Changchun Univ Chinese Med, Sch Pharm, Changchun, Peoples R China

[4] Jilin Univ, Hosp Stomatol, Jilin Prov Key Lab Tooth Dev & Bone Remodeling, Changchun, Peoples R China

来源：

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY | 2022年 / 10卷

关键词：

gene expression; long non-coding RNA; oral cancer; pathogenesis; XIST; SQUAMOUS-CELL CARCINOMA; LONG NONCODING RNAS; PROMOTES PROLIFERATION; CISPLATIN RESISTANCE; METHYLATION; PROGRESSION; BREAST; INACTIVATION; MECHANISMS; STRATEGIES;

D O I：

10.3389/fcell.2022.826650

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Long non-coding RNA (lncRNA) plays a significant role in the pathogenesis of many human malignant tumors, including oral cancer. LncRNA can act as a gene regulator in a variety of cancers. It regulates the growth of malignant cells via many cellular signal pathways such as the PI3K (phosphoinositide 3-kinase)/AKT (alpha-serine/threonine-protein kinase) pathway. In this review, we have analyzed the role of lncRNAs, such as lncRNA X inactive specific transcript (XIST), in oral cancer, including its effects on the proliferation, apoptosis, invasion, migration, and resistance to chemotherapy of oral cancer. We have also focused on the role of lncRNA XIST as the core of X chromosome inactivation. Here, we provide a brief overview of the role of many kinds of lncRNAs, including XIST, which provides a theoretical basis for the study of the role of XIST in oral cancer. Our review may provide a new direction for the study of the occurrence, development, and prognosis of oral cancer and provide a new target for its treatment.

引用

页数：10

共 50 条

[31] Role of lncRNAs in the cancer development and progression and their regulation by various phytochemicals
Baskaran, Rathinasamy
Velmurugan, Bharath Kumar
BIOMEDICINE & PHARMACOTHERAPY, 2018, 102 : 242 - 248
[32] Novel role of lncRNAs regulatory network in papillary thyroid cancer
Su, Yuanhao
Mei, Lin
Jiang, Tiantian
Wang, Zhidong
Ji, Yuanyuan
BIOCHEMISTRY AND BIOPHYSICS REPORTS, 2024, 38
[33] GH and IGF System: The Regulatory Role of miRNAs and lncRNAs in Cancer
Catellani, Cecilia
Ravegnini, Gloria
Sartori, Chiara
Angelini, Sabrina
Street, Maria E.
FRONTIERS IN ENDOCRINOLOGY, 2021, 12
[34] Role of lncRNAs as Novel Biomarkers and Therapeutic Targets in Ovarian Cancer
Fu, Lu-lu
Li, Chun-jin
Xu, Ying
Li, Ling-yun
Zhou, Xu
Li, Dan-dan
Chen, Shu-xiong
Wang, Feng-ge
Zhang, Xue-ying
Zheng, Lian-wen
CRITICAL REVIEWS IN EUKARYOTIC GENE EXPRESSION, 2017, 27 (02): : 183 - 195
[35] Dormancy in Breast Cancer, the Role of Autophagy, lncRNAs, miRNAs and Exosomes
Jahangiri, Leila
Ishola, Tala
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2022, 23 (09)
[36] Identifying the role of hypoxia-related lncRNAs in pancreatic cancer
Sun, Jing
Zhu, Shuai
GENOMICS, 2023, 115 (05)
[37] The diagnostic role and mechanistic functions of exosomal lncRNAs in prostate cancer
Hangsheng Zhou
Hongyuan Wan
Yanyan Feng
Lijie Zhu
Yuanyuan Mi
Clinical and Translational Oncology, 2023, 25 : 592 - 600
[38] The function of LncRNAs and their role in the prediction, diagnosis, and prognosis of lung cancer
Chen, Yu
Zitello, Emory
Guo, Rui
Deng, Youping
CLINICAL AND TRANSLATIONAL MEDICINE, 2021, 11 (04):
[39] Role of hypermethylated-lncRNAs in the prognosis of bladder cancer patients
Luo, Junhua
Xu, Jinming
Ou, Longhua
Zhou, Yingchen
Yun, Haichao
Yang, Yu
Wu, Xionghui
Wang, Yan
JOURNAL OF INTERNATIONAL MEDICAL RESEARCH, 2021, 49 (10)
[40] Challenges and perspectives for structural biology of lncRNAs-the example of the Xist lncRNA A-repeats
Jones, Alisha N.
Sattler, Michael
JOURNAL OF MOLECULAR CELL BIOLOGY, 2019, 11 (10) : 845 - 859

← 1 2 3 4 5 →