Highly enantioselective and regioselective biocatalytic azidolysis of aromatic epoxides

被引：1
|
作者：
Spelberg, JHL [1 ]
Vlieg, JETV
Tang, LX
Janssen, DB
Kellogg, RM
机构：
[1] Univ Groningen, Groningen Biomol Sci & Biotechnol Inst, Dept Biochem, NL-9747 AG Groningen, Netherlands
[2] Univ Groningen, Dept Organ & Mol Inorgan Chem, NL-9747 AG Groningen, Netherlands
来源：
ORGANIC LETTERS | 2001年 / 3卷 / 01期
关键词：
D O I：
暂无
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
[GRAPHICS] The halohydrin dehalogenase from Agrobacterium radiobacter AD1 catalyzed the highly enantioselective and beta -regioselective azidolysis of (substituted) styrene oxides. By means of kinetic resolutions the remaining epoxide and the formed azido alcohol could be obtained in very high ee. In a large scale conversion, the decrease in yield and selectivity due to the uncatalyzed chemical side reaction could be overcome by slow addition of azide.
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页码：41 / 43
页数：3
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