Non-steroidal anti-inflammatory drugs and variceal bleeding: A case-control study

被引:17
|
作者
deLedinghen, V
Mannant, PR
Foucher, J
Perault, MC
Barrioz, T
Ingrand, P
Vandel, B
Silvain, C
Beauchant, M
机构
[1] CHU POITERS,SERV HEPATOL,POITIERS,FRANCE
[2] CHU POITERS,SERV PHARMACOL CLIN,POITIERS,FRANCE
[3] CHU POITERS,UNITE BIOSTAT,POITIERS,FRANCE
关键词
esophageal variceal bleeding; nonsteroidal anti-inflammatory drugs; portal hypertension;
D O I
10.1016/S0168-8278(96)80142-5
中图分类号
R57 [消化系及腹部疾病];
学科分类号
摘要
Background/Aim: The aim of this case-control study was to assess the risk of bleeding from esophageal varices associated with aspirin and non-steroidal anti-inflammatory drug consumption. Methods: Between January 1992 and May 1994, patients admitted for bleeding from esophageal or gastric lesions related to portal hypertension were matched with a control patient of the same age and sex, who was free of gastrointestinal bleeding, A structured interview was conducted with the cases and controls to determine drug consumption during the 2 weeks preceding admission, Fifty-nine cases and 59 controls were recruited. Results/Conclusions: Use of aspirin was more prevalent among the cases than the controls (odds ratio 3.81; 95% confidence interval 1.36-11.64; p=0.004). This difference remained significant in the subgroups of patients with a first episode of variceal bleeding (odds ratio 3.9; 95% confidence interval 1.2-13.9, p=0.01), but was not significant in the subgroups of patients with a recurrent episode of variceal bleeding, The use of aspirin was associated with a high risk of a first episode of variceal bleeding, suggesting that patients with portal hypertension should avoid taking these drugs.
引用
收藏
页码:570 / 573
页数:4
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