Acute acetaminophen toxicity in adults

被引:12
|
作者
Saccomano, Scott J. [1 ]
机构
[1] Univ N Carolina, Wilmington, NC 28403 USA
来源
NURSE PRACTITIONER | 2019年 / 44卷 / 11期
关键词
acetaminophen; hepatotoxicity; N-acetylcysteine (NAC); N-acetyl-p-aminophenol (APAP); N-acetyl-p-benzoquinone imine (NAPQI); paracetamol; Rumack-Matthew nomogram; HEPATOTOXICITY;
D O I
10.1097/01.NPR.0000586020.15798.c6
中图分类号
R47 [护理学];
学科分类号
1011 ;
摘要
When taken in the recommended dosage, acetaminophen is a safe and effective analgesic and antipyretic agent. Its wide availability and easy accessibility make accidental or intentional overdose, leading to hepatotoxicity, a common occurrence. To prevent morbidity and mortality, prompt recognition of acetaminophen toxicity is essential. This article covers the stages of acetaminophen toxicity, recommended treatments, and NP considerations, including patient education recommendations.
引用
收藏
页码:42 / 47
页数:6
相关论文
共 50 条
  • [41] ACETAMINOPHEN CHRONIC TOXICITY
    REGAL, RE
    DRUG INTELLIGENCE & CLINICAL PHARMACY, 1986, 20 (06): : 507 - 507
  • [42] Acetaminophen toxicity in children
    Sachs, HP
    AMERICAN FAMILY PHYSICIAN, 2002, 66 (05) : 734 - 734
  • [43] Chronic acetaminophen toxicity
    Roberge, R
    JOURNAL OF EMERGENCY MEDICINE, 2003, 25 (04): : 474 - 474
  • [44] ACETAMINOPHEN TOXICITY - REPLY
    MADAN, PL
    DRUG INTELLIGENCE & CLINICAL PHARMACY, 1978, 12 (01): : 57 - 57
  • [45] Serum acetaminophen adducts reliably distinguish acetaminophen toxicity from other causes of acute liver failure.
    Davern, TJ
    James, LP
    Fontana, RJ
    Larson, AM
    Polson, J
    Lalani, E
    Hinson, JA
    Lee, WM
    HEPATOLOGY, 2003, 38 (04) : 538A - 539A
  • [46] Elevated Acetaminophen-Cysteine Adducts Facilitate Diagnosis of Acetaminophen Toxicity in a Case of Unexplained Acute Liver Failure
    Wiegand, T. J.
    Gorodetsky, R. M.
    Green, J. L.
    Dart, R. C.
    CLINICAL TOXICOLOGY, 2012, 50 (04) : 303 - 303
  • [47] ACETAMINOPHEN TOXICITY REDUCED WITH ACETAMINOPHEN-METHIONINE COMBINATION
    NEUVONEN, PJ
    TOKOLA, O
    TOIVONEN, ML
    SIMELL, O
    CLINICAL PHARMACOLOGY & THERAPEUTICS, 1985, 37 (02) : 217 - 217
  • [48] Isolated Acute Pancreatitis in the Absence of Liver Damage: Unreported Complication of Acetaminophen Toxicity
    Virk, Muhammad
    Anand, Sury
    Changela, Kinesh
    Shah, Sunil
    AMERICAN JOURNAL OF GASTROENTEROLOGY, 2012, 107 : S325 - S325
  • [49] Effects of hydrogen sulfide on acetaminophen-induced acute renal toxicity in rats
    Ozatik, Fikriye Yasemin
    Teksen, Yasemin
    Kadioglu, Emine
    Ozatik, Orhan
    Bayat, Zeynep
    INTERNATIONAL UROLOGY AND NEPHROLOGY, 2019, 51 (04) : 745 - 754
  • [50] Acute toxicity of mixture of acetaminophen and ibuprofen to Green Neon Shrimp, Neocaridina denticulate
    Sung, Hung-Hung
    Chiu, Yuh-Wen
    Wang, Shu-Yin
    Chen, Chien-Min
    Huang, Da-Ji
    ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY, 2014, 38 (01) : 8 - 13