A new synthesis of β-amino acids by use of ketene diethyl acetal as enolate equivalent

被引:7
|
作者
Rossen, K
Jakubec, P
Kiesel, M
Janik, M
机构
[1] Degussa AG, EC EX R&D WO, D-63457 Hanau, Germany
[2] Degussa AG, Aqura NMR Dept, D-63457 Hanau, Germany
关键词
beta-amino acid; ketene diethylacetal; acyl imine; acetate enolate; enzymic kinetic resolution;
D O I
10.1016/j.tetlet.2005.01.114
中图分类号
O62 [有机化学];
学科分类号
070303 ; 081704 ;
摘要
Reaction of phenylsulfonyl formamides, readily available in a single step from an aromatic aldehyde and sodium phenylsulfinate, with ketene diethyl acetal under basic conditions gives N-formyl beta-amino acid esters in good yield, which can be kinetically resolved with a lipase. (C) 2005 Elsevier Ltd. All rights reserved.
引用
收藏
页码:1819 / 1821
页数:3
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