A new synthesis of β-amino acids by use of ketene diethyl acetal as enolate equivalent

被引：7
|
作者：
Rossen, K
Jakubec, P
Kiesel, M
Janik, M
机构：
[1] Degussa AG, EC EX R&D WO, D-63457 Hanau, Germany
[2] Degussa AG, Aqura NMR Dept, D-63457 Hanau, Germany
来源：
TETRAHEDRON LETTERS | 2005年 / 46卷 / 11期
关键词：
beta-amino acid; ketene diethylacetal; acyl imine; acetate enolate; enzymic kinetic resolution;
D O I：
10.1016/j.tetlet.2005.01.114
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Reaction of phenylsulfonyl formamides, readily available in a single step from an aromatic aldehyde and sodium phenylsulfinate, with ketene diethyl acetal under basic conditions gives N-formyl beta-amino acid esters in good yield, which can be kinetically resolved with a lipase. (C) 2005 Elsevier Ltd. All rights reserved.
引用
收藏
页码：1819 / 1821
页数：3
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