ABC transporters and their impact on pathogenesis and drug sensitivity

被引：3
|
作者：
Andrade, AC [1 ]
Zwiers, LH [1 ]
De Waard, MA [1 ]
机构：
[1] Wageningen Agr Univ, Phytopathol Lab, NL-6700 EE Wageningen, Netherlands
来源：
PESTICIDE CHEMISTRY AND BIOSCIENCE: THE FOOD-ENVIRONMENT CHALLENGE | 1999年 / 233期
关键词：
D O I：
10.1533/9781845698416.5.221
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
This review presents an outline of the multifunctional properties of ABC transporters in different biological systems. A well known function of these transport proteins is protection of organisms against toxic compounds. This also applies to plant pathogens. We propose that ABC transporters can play an important role in plant pathogenesis and fungicide sensitivity and thus can be regarded as potential target sites for the discovery of new biologically active compounds.
引用
收藏
页码：221 / 235
页数：15
相关论文
共 50 条
  • [41] Apical ABC Transporters and Cancer Chemotherapeutic Drug Disposition
    Durmus, Selvi
    Hendrikx, Jeroen J. M. A.
    Schinkel, Alfred H.
    [J]. ABC TRANSPORTERS AND CANCER, 2015, 125 : 1 - 41
  • [42] Drug transport across the placenta, role of the ABC drug efflux transporters
    Behravan, Javad
    Piquette-Miller, Micheline
    [J]. EXPERT OPINION ON DRUG METABOLISM & TOXICOLOGY, 2007, 3 (06) : 819 - 830
  • [43] Glutathione and ABC transporters as determinants of sensitivity to oxidative and nitrosative stress
    Tew, KD
    Boyd, JT
    Chen, ZJJ
    Davis, W
    Fazilev, F
    Findlay, V
    Gaté, L
    Ile, K
    Soulika, A
    Townsend, DM
    [J]. JOURNAL OF NUTRITION, 2004, 134 (11): : 3205S - 3206S
  • [44] Placental ABC Transporters: Biological Impact and Pharmaceutical Significance
    Joshi, Anand A.
    Vaidya, Soniya S.
    St-Pierre, Marie V.
    Mikheev, Andrei M.
    Desino, Kelly E.
    Nyandege, Abner N.
    Audus, Kenneth L.
    Unadkat, Jashvant D.
    Gerk, Phillip M.
    [J]. PHARMACEUTICAL RESEARCH, 2016, 33 (12) : 2847 - 2878
  • [45] ABC Multidrug Transporters: Target for Modulation of Drug Pharmacokinetics and Drug-Drug Interactions
    Marquez, Beatrice
    Van Bambeke, Francoise
    [J]. CURRENT DRUG TARGETS, 2011, 12 (05) : 600 - 620
  • [46] Placental ABC Transporters: Biological Impact and Pharmaceutical Significance
    Anand A. Joshi
    Soniya S. Vaidya
    Marie V. St-Pierre
    Andrei M. Mikheev
    Kelly E. Desino
    Abner N. Nyandege
    Kenneth L. Audus
    Jashvant D. Unadkat
    Phillip M. Gerk
    [J]. Pharmaceutical Research, 2016, 33 : 2847 - 2878
  • [47] Transporters and their impact on drug disposition
    Beringer, PM
    Slaughter, RL
    [J]. ANNALS OF PHARMACOTHERAPY, 2005, 39 (06) : 1097 - 1108
  • [48] The complexities of antiretroviral drug-drug interactions: role of ABC and SLC transporters
    Kis, Olena
    Robillard, Kevin
    Chan, Gary N. Y.
    Bendayan, Reina
    [J]. TRENDS IN PHARMACOLOGICAL SCIENCES, 2010, 31 (01) : 22 - 35
  • [49] ABC Transporters and Drug Efflux at the Blood-Brain Barrier
    Shen, Shanshan
    Zhang, Wandong
    [J]. REVIEWS IN THE NEUROSCIENCES, 2010, 21 (01) : 29 - 53
  • [50] ABC Transporters in Multidrug Resistance and Pharmacokinetics, and Strategies for Drug Development
    Choi, Young Hee
    Yu, Ai-Ming
    [J]. CURRENT PHARMACEUTICAL DESIGN, 2014, 20 (05) : 793 - 807
12345