The solution conformation of C-glycosyl analogues of the sialyl-Tn antigen

被引：2
|
作者：
Garcia-Aparicio, Victor
Malapelle, Andeline
Abdallah, Zouleika
Doisneau, Gilles
Santos, Jose Ignacio
Asensio, Juan Luis
Canada, Francisco Javier
Beau, Jean Marie [1 ]
Jimenez-Barbero, Jesus
机构：
[1] Univ Paris 11, Inst Chim Mol & Mat, CNRS, Lab Synth Biomol, F-91405 Orsay, France
[2] CSIC, Ctr Invest Biol, Madrid 28040, Spain
来源：
CARBOHYDRATE RESEARCH | 2007年 / 342卷 / 12-13期
关键词：
NMR; glycomimetics; C-glycosides; conformational analysis; molecular mechanics;
D O I：
10.1016/j.carres.2007.03.021
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The conformational behavior of two C-glycosyl analogues of the sialyl-Tn antigen has been determined by a combination of NMR methods and molecular mechanics calculations. Both compounds show a major solution conformation that is drastically different from the major one of the natural compound. (c) 2007 Elsevier Ltd. All rights reserved.
引用
收藏
页码：1974 / 1982
页数：9
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