Insights from the molecular docking analysis of colistin with the PmrA protein model from Acinetobacter baumannii

被引:1
|
作者
Ganeshan, Shalini [1 ]
Shakibaie, Mohammad Reza [2 ,3 ]
Rajagopal, Rajaguru [4 ]
机构
[1] Tips Coll Arts & Sci, Dept Biotechnol, Coimbatore 641107, Tamil Nadu, India
[2] Kerman Univ Med Sci, Dept Microbiol & Virol, Kerman, Iran
[3] Kerman Univ Med Sci, Environm Hlth Engn Res Ctr, Kerman, Iran
[4] Mother Theresa Post Grad & Res Inst Hlth Sci, Dept Pharmaceut, Pondicherry 605006, India
关键词
Acinetobacter baumannii; protein modeling; model quality; molecular docking; RESISTANCE;
D O I
10.6026/97320630018041
中图分类号
Q [生物科学];
学科分类号
07 ; 0710 ; 09 ;
摘要
Acinetobacter baumannii (AB) is one of the most common causes of nosocomial infections. Therefore, it is of interest to design and develop drugs against Acinetobacter baumannii. A strain of AB showing MIC 32 mu g/ml against colistin was isolated from a hospital environment in Iran. Hence, we document data to glean insights from the molecular docking analysis of colistin with the PmrA protein from this bacterium.
引用
收藏
页码:41 / 49
页数:9
相关论文
共 50 条
  • [31] Analyzing pmrA and pmrB genes in Acinetobacter baumannii resistant to colistin in Shahid Rajai Shiraz, Iran Hospital by PCR: First report in Iran
    Sepahvand, Shahriar
    Doudi, Monir
    Davarpanah, Mohammad Ali
    Bahador, Abbas
    Ahmadi, Mehranoosh
    PAKISTAN JOURNAL OF PHARMACEUTICAL SCIENCES, 2016, 29 (04) : 1401 - 1406
  • [32] Molecular docking and simulation of the interaction of sulbactam with Acinetobacter baumannii BaeSR and AdeSR
    Ho, Kun-hsuan
    Su, Shey-chiang
    Lee, Kuan-rong
    BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2021, 580 : 81 - 86
  • [33] Mechanistic and structural insights into the bifunctional enzyme PaaY from Acinetobacter baumannii
    Jiao, Min
    He, Wenbo
    Ouyang, Zhenlin
    Qin, Qian
    Guo, Yucheng
    Zhang, Jiaxin
    Bai, Yixin
    Guo, Xiaolong
    Yu, Qinyue
    She, Junjun
    Hwang, Peter M.
    Zheng, Fang
    Wen, Yurong
    STRUCTURE, 2023, 31 (08) : 935 - +
  • [34] High rates of resistance to colistin and polymyxin B in subgroups of Acinetobacter baumannii isolates from Korea
    Ko, Kwan Soo
    Suh, Ji Yoeun
    Kwon, Ki Tae
    Jung, Sook-In
    Park, Kyong-Hwa
    Kang, Cheol In
    Chung, Doo Ryeon
    Peck, Kyong Ran
    Song, Jae-Hoon
    JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, 2007, 60 (05) : 1163 - 1167
  • [35] Molecular Characterization of Carbapenem/Colistin-Resistant Acinetobacter baumannii Clinical Isolates from Egypt by Whole-Genome Sequencing
    Fam, Nevine S.
    Gamal, Doaa
    Mohamed, Sara H.
    Wasfy, Reham M.
    Soliman, May S.
    El-Kholy, Amani A.
    Higgins, Paul G.
    INFECTION AND DRUG RESISTANCE, 2020, 13 : 4487 - 4493
  • [36] Unique Structural Modifications Are Present in the Lipopolysaccharide from Colistin-Resistant Strains of Acinetobacter baumannii
    Pelletier, Mark R.
    Casella, Leila G.
    Jones, Jace W.
    Adams, Mark D.
    Zurawski, Daniel V.
    Hazlett, Karsten R. O.
    Doi, Yohei
    Ernst, Robert K.
    ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2013, 57 (10) : 4831 - 4840
  • [37] Molecular mechanisms of colistin resistance mediated by pmrCAB genes in Acinetobacter baumannii isolated from patients hospitalized in Isfahan medical centers
    Abbasi, Ali
    Hajihashemi, Bahareh
    Shokri, Dariush
    POSTEPY HIGIENY I MEDYCYNY DOSWIADCZALNEJ, 2024, 78 (01): : 52 - 57
  • [38] Prevalence and molecular mechanisms of colistin resistance in Acinetobacter baumannii clinical isolates in Tehran, Iran
    Khoshbayan, Amin
    Shariati, Aref
    Shahmoradi, Samane
    Baseri, Zohre
    Mozafari, Haniyeh
    Darban-Sarokhalil, Davood
    ACTA MICROBIOLOGICA ET IMMUNOLOGICA HUNGARICA, 2021, 68 (04) : 262 - 266
  • [39] Screening of potential lead molecules against prioritised targets of multi-drug-resistant-Acinetobacter baumannii - insights from molecular docking, molecular dynamic simulations and in vitro assays
    Skariyachan, Sinosh
    Manjunath, Meghna
    Bachappanavar, Nikhil
    JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS, 2019, 37 (05): : 1146 - 1169
  • [40] Analysis of the Extracellular Proteome of Colistin-Resistant Korean Acinetobacter baumannii Strains
    Lee, Sang-Yeop
    Yun, Sung Ho
    Lee, Hayoung
    Yi, Yoon-Sun
    Park, Edmond Changkyun
    Kim, Wooyoung
    Kim, Hye-Yeon
    Lee, Je Chul
    Kim, Gun-Hwa
    Kim, Seung Il
    ACS OMEGA, 2020, 5 (11): : 5713 - 5720