Boron neutron capture therapy for glioblastoma: improvement of boron biodistribution by hyaluronidase

被引：8
|
作者：
Haselsberger, K
Radner, H
Pendl, C
机构：
[1] Karl Franzens Univ Graz, Dept Neurosurg, A-8036 Graz, Austria
[2] Karl Franzens Univ Graz, Inst Pathol, A-8036 Graz, Austria
来源：
CANCER LETTERS | 1998年 / 131卷 / 01期
关键词：
boron neutron capture therapy; BSH; glioblastoma; hyaluronidase;
D O I：
10.1016/S0304-3835(98)00206-7
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Boron neutron capture therapy (BNCT) represents a highly promising therapeutic alternative for the treatment of the most common malignant brain tumor, glioblastoma multiforme. Both the efficacy and safety of BNCT are greatly dependent on the pattern of B-10 biodistribution. The present study investigates the influence of systemic hyaluronidase applied in combination with Na2B12H11SH (BSH), a boron carrier used in current clinical trials. The application of hyaluronidase was associated with a statistically significant improvement in the tumor/blood boron concentration ratio which suggests that hyaluronidase is capable of enhancing the therapeutic potential of BSH. (C) 1998 Elsevier Science Ireland Ltd. All rights reserved.
引用
收藏
页码：109 / 111
页数：3
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