Novel chiral imidazole cyclophane receptors: synthesis and enantioselective recognition for amino acid derivatives

被引：82

作者：

You, JS

Yu, XQ

Zhang, GL

Xiang, QX

Lan, JB

Xie, RG ^{[1
]}

机构：

[1] Sichuan Univ, Dept Chem, Chengdu 610064, Peoples R China

[2] Chinese Acad Sci, Chengdu Inst Biol, Chengdu 610041, Peoples R China

来源：

CHEMICAL COMMUNICATIONS | 2001年 / 18期

关键词：

D O I：

10.1039/b103325p

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Novel chiral imidazole cyclophane receptors were synthesized by highly selective N-alkylation of the imidazolyl 1N-position of the bridged histidine diester 2 with the dibromide in the presence of NaH; these receptors exhibit good chiral recognition toward the enantiomers Of L- and D-amino acid derivatives (up to K-D/K-L = 3.52, Delta DeltaG(0) = -3.11 kJ mol(-1)) in CHCl3 at 25.0 degreesC.

引用

页码：1816 / 1817

页数：2

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