Impact of reoxygenation with oxygen and air on the extent of the brain damage after hypoxia-ischaemia in neonatal rats

被引：0
|
作者：
Bagenholm, R
Hagberg, H
Kjellmer, I
机构：
[1] GOTHENBURG UNIV, DEPT PEDIAT, S-41390 GOTHENBURG, SWEDEN
[2] GOTHENBURG UNIV, DEPT OBSTET & GYNECOL, S-41390 GOTHENBURG, SWEDEN
来源：
ACTA PAEDIATRICA | 1996年 / 85卷 / 10期
关键词：
animal; brain damage; free radicals; perinatal; reoxygenation;
D O I：
暂无
中图分类号：
R72 [儿科学];
学科分类号：
100202 ;
摘要：
Brain damage after hypoxia-ischaemia develops partly during the state of reoxygenation. The generation of free oxygen radicals is considered to be one possible mechanism. In order to evaluate the role of hyperoxygenation, a comparison was made between reoxygenation with pure oxygen and with air after hypoxia-ischaemia in a rat model of unilateral cerebral hemisphere damage. Brain damage was induced in 7-day-old rats. The animals were treated during reoxygenation with either 100% oxygen for 0.5 h or air. The extent of the brain damage was determined at 3 weeks of age by weighing the left and right hemispheres separately. No significant difference in weight deficit of the hemispheres was seen in the oxygen-treated group (15.5%, median) compared to the air-treated group (25.0%). Reoxygenation with pure oxygen after hypoxia-ischaemia in neonatal rats does not cause increased brain damage compared with reoxygenation with room air.
引用
收藏
页码：1228 / 1231
页数：4
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