Synthesis of Alkylated Amides and Amines by Cu(OTf) 2-Catalyzed N-Alkylation of Nitriles and Amines with Alcohols

被引：6

作者：

Ma, Xiantao ^{[1
,2
]}

Li, Bo ^{[2
]}

Xiao, Yinglin ^{[1
]}

Yu, Xiaochun ^{[2
]}

Su, Chenliang ^{[1
,2
]}

Xu, Qing ^{[1
,2
]}

机构：

[1] Shenzhen Univ, SZU NUS Collaborat Innovat Ctr Optoelect Sci & Te, Key Lab Optoelect Devices & Syst, Minist Educ & Guangdong Prov,Coll Optoelect Engn, Shenzhen 518060, Peoples R China

[2] Wenzhou Univ, Coll Chem & Mat Engn, Wenzhou 325035, Peoples R China

来源：

CHINESE JOURNAL OF ORGANIC CHEMISTRY | 2017年 / 37卷 / 08期

基金：

中国博士后科学基金; 中国国家自然科学基金;

关键词：

Alcohols; N-Alkylation; Amides; Amines; Copper Catalysis; Nitriles; Ritter Reaction; RITTER REACTION; ACID; SULFONAMIDES; AMIDATION; AMINATION; EFFICIENT; CATALYST;

D O I：

10.6023/cjoc201703028

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

An efficient method for synthesis of the useful N-alkyl amides is achieved by a low loading Cu(OTf)(2)-catalyzed Ritter reaction of nitriles with secondary alcohols and some primary alcohols. The same method can be extended to dehydrative N-alkylation of anilines with secondary alcohols to obtain N-alkylated anilines.

引用

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页码：2034 / 2043

页数：10

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