The first palladium-catalyzed desulfitative Sonogashira-type cross-coupling of (hetero)aryl thioethers with terminal alkynes

被引：68
|
作者：
Mehta, Vaibhav Pravinchandra [1 ]
Sharma, Anuj [1 ]
Van der Eycken, Erik [1 ]
机构：
[1] Katholieke Univ Leuven, Dept Chem, LOMAC, B-3001 Heverlee, Belgium
来源：
ORGANIC LETTERS | 2008年 / 10卷 / 06期
关键词：
D O I：
10.1021/ol800054b
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
An unprecedented desulfitative Sonogashira-type cross-coupling protocol is exemplified by the synthesis of substituted 5-chloro-3-alkynylpyrazinones from the corresponding 5-chloro-3-(phenylsulfanyl) pyrazin-2(1H)-ones. The applicability of the method is extended to solid-phase linked pyrazin-2(1H)-ones as well as to some oxazinones, pyrazines, and phenyl thioesters.
引用
收藏
页码：1147 / 1150
页数：4
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