Membrane Trafficking: An Endosome Tether Meets a Rab and Collapses

被引：3
|
作者：
Das, Sanchaita
Lambright, David G. [1 ]
机构：
[1] Univ Massachusetts, Sch Med, Program Mol Med, Worcester, MA 01605 USA
来源：
CURRENT BIOLOGY | 2016年 / 26卷 / 20期
关键词：
AUTOANTIGEN; 1; EEA1; FUSION; ARCHITECTURE; DETERMINANTS; VESICLES; BINDING; DOCKING; PROTEIN; COMPLEX; FINGER;
D O I：
10.1016/j.cub.2016.08.056
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Long-range tethering is a ubiquitous recognition event preceding membrane fusion. A new study shows that Rab GTPase binding causes 'entropic collapse' of the coiled-coil endosome tether EEA1, driving membrane apposition and facilitating short-range interactions required for fusion.
引用
收藏
页码：R927 / R929
页数：3
相关论文
共 50 条
  • [31] Regulation of membrane trafficking: Structural insights from a Rab/effector complex
    Gonzalez, L
    Scheller, RH
    CELL, 1999, 96 (06) : 755 - 758
  • [32] Versatile role of Rab27 in membrane trafficking: Focus on the Rab27 effector families
    Fukuda, M
    JOURNAL OF BIOCHEMISTRY, 2005, 137 (01): : 9 - 16
  • [33] Rab35 GTPase and cancer: Linking membrane trafficking to tumorigenesis
    Shaughnessy, Ronan
    Echard, Arnaud
    TRAFFIC, 2018, 19 (04) : 247 - 252
  • [34] Molecular insights into tether function at the late endosome and vacuole
    Ungermann, Christian
    FASEB JOURNAL, 2012, 26
  • [35] Membrane translocation of diphtheria toxin fragment - A exploits early to late endosome trafficking machinery
    Lemichez, E
    Bomsel, M
    Devilliers, G
    vanderSpek, J
    Murphy, JR
    Lukianov, EV
    Olsnes, S
    Boquet, P
    MOLECULAR MICROBIOLOGY, 1997, 23 (03) : 445 - 457
  • [36] A Tether is a Tether is a Tether: Tethering at Membrane Contact Sites
    Eisenberg-Bord, Michel
    Shai, Nadav
    Schuldiner, Maya
    Bohnert, Maria
    DEVELOPMENTAL CELL, 2016, 39 (04) : 395 - 409
  • [37] POSTTRANSLATIONAL PROCESSING AND MEMBRANE ASSOCIATION OF THE 2 EARLY ENDOSOME-ASSOCIATED RAB GTP-BINDING PROTEINS (RAB4 AND RAB5)
    LI, GP
    STAHL, PD
    ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS, 1993, 304 (02) : 471 - 478
  • [38] Plant signaling endosomes and endosome trafficking
    N. L. Klyachko
    Russian Journal of Plant Physiology, 2010, 57 : 290 - 296
  • [39] Reconstitution of TGN to endosome trafficking in vitro
    Cook, NR
    Row, PE
    Davidson, HW
    MOLECULAR BIOLOGY OF THE CELL, 2001, 12 : 484A - 484A
  • [40] Rab GTPase Function in Endosome and Lysosome Biogenesis
    Langemeyer, Lars
    Froehlich, Florian
    Ungermann, Christian
    TRENDS IN CELL BIOLOGY, 2018, 28 (11) : 957 - 970
12345