Predictive factors and impact of full donor T-cell chimerism after reduced intensity conditioning allogeneic stem cell transplantation

被引：61
|
作者：
Mohty, Mohamad [1 ,2 ,3 ]
Avinens, Odile [4 ]
Faucher, Catherine [1 ]
Viens, Patrice [5 ]
Blaise, Didier [1 ,2 ,3 ]
Eliaou, Jean-Francois [4 ]
机构：
[1] Inst Paoli Calmettes, UTTC, Marseille, France
[2] Univ Mediterranee, Fac Med, Marseille, France
[3] INSERM, UMR 599, Marseille, France
[4] CHU Montpellier, Hop St Eloi, Lab Immunol, Montpellier, France
[5] Inst Paoli Calmettes, Dept Oncol Med, Marseille, France
来源：
HAEMATOLOGICA | 2007年 / 92卷 / 07期
关键词：
D O I：
10.3324/haematol.10971
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
This study investigated the kinetics of CD3+-T cell chimerism (TCC) in 102 patients receiving reduced intensity conditioning allogeneic stem cell transplantation (RIC-allo-SCT) from an HLA-identical sibling. Patients with full donor TCC at day 30 had a higher incidence of grade 2-4 acute GVHD compared to patients in mixed TCC (cumulative-incidence, 61% vs. 35%; p=0.01). The delayed establishment of full donor TCC in myeloid malignancies was associated with a higher incidence of relapse (40% vs. 0; p=0.002), suggesting that monitoring of the kinetics of TCC is mandatory after RIC-allo-SCT.
引用
收藏
页码：1004 / 1006
页数：3
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