Thalamic neurochemical abnormalities in individuals with prodromal symptoms of schizophrenia - Relationship to auditory event-related potentials

被引：23
|
作者：
Stone, James M. [1 ,2 ]
Bramon, Elvira [2 ]
Pauls, Astrid [2 ]
Sumich, Alex [2 ,3 ]
McGuire, Philip K. [2 ]
机构：
[1] Univ London Imperial Coll Sci Technol & Med, Hammersmith Hosp, Div Expt Med, London W12 0NN, England
[2] Kings Coll London, Inst Psychiat, Dept Psychol Med & Psychiat, London SE5 8AF, England
[3] Nottingham Trent Univ, Sch Social Sci, Div Psychol, Nottingham NG1 4BU, England
来源：
PSYCHIATRY RESEARCH-NEUROIMAGING | 2010年 / 183卷 / 02期
基金：
英国医学研究理事会;
关键词：
EEG; Mismatch negativity; P300; Glutamate/glutamine; NAA; Magnetic resonance spectroscopy [MRS; PSYCHOSIS; P300; PEOPLE; FAMILY; RISK; ERP;
D O I：
10.1016/j.pscychresns.2010.05.004
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
Thalamic neurochemical abnormalities may underlie psychotic symptoms and auditory event-related potential (ERP) abnormalities in schizophrenia. We investigated this hypothesis in subjects at risk of psychosis using magnetic resonance spectroscopy and electroencephalography (EEG). Reduced thalamic glutamate plus glutamine and N-acetyl aspartate levels were associated with abnormal frontal ERPs, supporting a thalamic basis for filtering impairments. (C) 2010 Elsevier Ireland Ltd. All rights reserved.
引用
收藏
页码：174 / 176
页数：3
相关论文
共 50 条
  • [21] Auditory event-related potentials (ERP) in first episode and chronic schizophrenia
    Umbricht, D
    Javitt, D
    Bates, J
    Pollak, S
    Lieberman, J
    Kane, J
    [J]. BIOLOGICAL PSYCHIATRY, 1997, 41 : 157 - 157
  • [22] Auditory event-related potentials in individuals with subjective and mild cognitive impairment
    Stuckenschneider, Tim
    Askew, Christopher D.
    Weber, Jan
    Abeln, Vera
    Rudiger, Stefanie
    Summers, Mathew J.
    Schneider, Stefan
    [J]. BEHAVIOURAL BRAIN RESEARCH, 2020, 391
  • [23] Event-related potentials to faces in schizophrenia
    Horley, K
    Gordon, E
    Gonsalvez, C
    Lazzaro, I
    Bahramali, H
    [J]. INTERNATIONAL JOURNAL OF PSYCHOPHYSIOLOGY, 2000, 35 (01) : 65 - 66
  • [24] Correlations of premorbid adjustment in schizophrenia with auditory event-related potential and neuropsychological abnormalities
    Levitt, JJ
    ODonnell, BF
    McCarley, RW
    Nestor, PG
    Shenton, ME
    [J]. AMERICAN JOURNAL OF PSYCHIATRY, 1996, 153 (10): : 1347 - 1349
  • [25] Neuropathological correlates of auditory event-related potentials in recent-onset schizophrenia
    Umbricht, D
    Bilder, R
    Wu, H
    Javitt, D
    Kane, J
    [J]. SCHIZOPHRENIA RESEARCH, 1998, 29 (1-2) : 124 - 124
  • [26] Clinical high risk and first episode schizophrenia: Auditory event-related potentials
    del Re, Elisabetta C.
    Spencer, Kevin M.
    Oribe, Naoya
    Mesholam-Gately, Raquelle I.
    Goldstein, Jill
    Shenton, Martha E.
    Petryshen, Tracey
    Seidman, Larry J.
    McCarley, Robert W.
    Niznikiewicz, Margaret A.
    [J]. PSYCHIATRY RESEARCH-NEUROIMAGING, 2015, 231 (02) : 126 - 133
  • [27] Auditory recovery cycle dysfunction in schizophrenia: A study using event-related potentials
    Clunas, NJ
    Ward, PB
    [J]. PSYCHIATRY RESEARCH, 2005, 136 (01) : 17 - 25
  • [28] AUDITORY EVENT-RELATED POTENTIALS IN CHILDREN AT RISK FOR SCHIZOPHRENIA - THE COMPLETE INITIAL SAMPLE
    FRIEDMAN, D
    CORNBLATT, B
    VAUGHAN, H
    ERLENMEYERKIMLING, L
    [J]. PSYCHIATRY RESEARCH, 1988, 26 (02) : 203 - 221
  • [29] Neuropathological correlates of auditory event-related potentials in recent-onset schizophrenia
    Umbricht, D
    Bilder, R
    Wu, H
    Javitt, D
    Kane, J
    [J]. BIOLOGICAL PSYCHIATRY, 1998, 43 : 125S - 125S
  • [30] Topography of auditory event-related potentials in PTSD
    Veltmeyer, M
    McFarlane, S
    Gordon, E
    Clark, CR
    [J]. AUSTRALIAN JOURNAL OF PSYCHOLOGY, 2005, 57 : 39 - 39
12345