Thalamic neurochemical abnormalities in individuals with prodromal symptoms of schizophrenia - Relationship to auditory event-related potentials

被引：23
|
作者：
Stone, James M. [1 ,2 ]
Bramon, Elvira [2 ]
Pauls, Astrid [2 ]
Sumich, Alex [2 ,3 ]
McGuire, Philip K. [2 ]
机构：
[1] Univ London Imperial Coll Sci Technol & Med, Hammersmith Hosp, Div Expt Med, London W12 0NN, England
[2] Kings Coll London, Inst Psychiat, Dept Psychol Med & Psychiat, London SE5 8AF, England
[3] Nottingham Trent Univ, Sch Social Sci, Div Psychol, Nottingham NG1 4BU, England
来源：
PSYCHIATRY RESEARCH-NEUROIMAGING | 2010年 / 183卷 / 02期
基金：
英国医学研究理事会;
关键词：
EEG; Mismatch negativity; P300; Glutamate/glutamine; NAA; Magnetic resonance spectroscopy [MRS; PSYCHOSIS; P300; PEOPLE; FAMILY; RISK; ERP;
D O I：
10.1016/j.pscychresns.2010.05.004
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
Thalamic neurochemical abnormalities may underlie psychotic symptoms and auditory event-related potential (ERP) abnormalities in schizophrenia. We investigated this hypothesis in subjects at risk of psychosis using magnetic resonance spectroscopy and electroencephalography (EEG). Reduced thalamic glutamate plus glutamine and N-acetyl aspartate levels were associated with abnormal frontal ERPs, supporting a thalamic basis for filtering impairments. (C) 2010 Elsevier Ireland Ltd. All rights reserved.
引用
收藏
页码：174 / 176
页数：3
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