Cardiac Adaptation to the Oncometabolite D-2-hydroxyglutarate is Driven by Alpha-Ketoglutarate and AcetylCoA

被引：0
|
作者：
Karlstaedt, Anja [1 ]
Khanna, Radhika [1 ]
Vasquez, Hernan [1 ]
Taegtmeyer, Heinrich [1 ]
机构：
[1] UTHealth, McGovern Med Sch, Houston, TX USA
来源：
CIRCULATION RESEARCH | 2017年 / 121卷
关键词：
D O I：
暂无
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
476
引用
收藏
页数：2
相关论文
共 50 条
  • [41] D-2-hydroxyglutarate impairs DNA repair through epigenetic reprogramming
    Lang, Fengchao
    Kaur, Karambir
    Fu, Haiqing
    Zaheer, Javeria
    Ribeiro, Diego Luis
    Aladjem, Mirit I.
    Yang, Chunzhang
    NATURE COMMUNICATIONS, 2025, 16 (01)
  • [42] Colonic inflammation and cancer are driven by elevated D-2-hydroxyglutarate levels in an EglN1-dependent mechanism
    Theiss, Arianne L.
    Han, Jie
    Turner, Kevin O.
    Genta, Robert M.
    Sweetman, Lawrence
    FASEB JOURNAL, 2017, 31
  • [43] Urinary alpha-hydroxyglutarate (alpha HG) and alpha-ketoglutarate (alpha KG) are not suitable probes for the labeling pattern of liver citric acid cycle (CAC).
    Yang, D
    Osborne, M
    Hazey, JW
    Brunengraber, H
    FASEB JOURNAL, 1996, 10 (03): : 1231 - 1231
  • [44] A d-2-hydroxyglutarate biosensor based on specific transcriptional regulator DhdR
    Dan Xiao
    Wen Zhang
    Xiaoting Guo
    Yidong Liu
    Chunxia Hu
    Shiting Guo
    Zhaoqi Kang
    Xianzhi Xu
    Cuiqing Ma
    Chao Gao
    Ping Xu
    Nature Communications, 12
  • [45] A d-2-hydroxyglutarate biosensor based on specific transcriptional regulator DhdR
    Xiao, Dan
    Zhang, Wen
    Guo, Xiaoting
    Liu, Yidong
    Hu, Chunxia
    Guo, Shiting
    Kang, Zhaoqi
    Xu, Xianzhi
    Ma, Cuiqing
    Gao, Chao
    Xu, Ping
    NATURE COMMUNICATIONS, 2021, 12 (01)
  • [46] THE ALPHA-KETOGLUTARATE RECEPTOR GPR99 REGULATES PATHOLOGICAL CARDIAC HYPERTROPHY
    Omede, Ameh
    Oceandy, Delvac
    Mamas, Mamas
    Cartwright, Elizabeth
    Zi, Min
    Prehar, Sukhpal
    Maqsood, Arfa
    HEART, 2014, 100 : A100 - A100
  • [47] Mutations in the D-2-hydroxyglutarate dehydrogenase gene cause D-2-hydroxyglutaric aciduria
    Struys, EA
    Salomons, GS
    Achouri, Y
    Van Schaftingen, E
    Grosso, S
    Craigen, WJ
    Verhoeven, NM
    Jakobs, C
    AMERICAN JOURNAL OF HUMAN GENETICS, 2005, 76 (02) : 358 - 360
  • [48] D-2-hydroxyglutarate suppresses allergic sensitization in a murine model of experimental asthma
    Tharakan, Anuj
    Kumar, Ankit
    Allegood, Jeremy
    Cowart, Lauren Ashley
    Conrad, Daniel H.
    Martin, Rebecca K.
    ALLERGY, 2023, 78 (11) : 3014 - +
  • [49] Elevated D-2-hydroxyglutarate during colitis drives progression to colorectal cancer
    Han, Jie
    Jackson, Dakota
    Holm, Janette
    Turner, Kevin
    Ashcraft, Paula
    Wang, Xuan
    Cook, Beth
    Arning, Erland
    Genta, Robert M.
    Venuprasad, K.
    Souza, Rhonda F.
    Sweetman, Lawrence
    Theiss, Arianne L.
    PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2018, 115 (05) : 1057 - 1062
  • [50] The Metabolic Intermediate Alpha-Ketoglutarate Suppresses the TGFβ-driven Profibrotic Responses of Dermal Fibroblasts
    Burja, Blaz
    Kania, Gabriela
    Tomsic, Matija
    Janko, Tea
    Sodin-Semrl, Snezna
    Distler, Oliver
    Lakota, Katja
    Frank-Bertoncelj, Mojca
    ARTHRITIS & RHEUMATOLOGY, 2019, 71
12345