Association of the FcεRIβ gene with bronchial hyper-responsiveness in an Italian population

被引：26
|
作者：
Trabetti, E
Cusin, V
Malerba, G
Martinati, LC
Casartelli, A
Boner, AL
Pignatti, PF
机构：
[1] Univ Verona, Inst Biol & Genet, I-37134 Verona, Italy
[2] Univ Verona, Dept Paediat, I-37100 Verona, Italy
来源：
JOURNAL OF MEDICAL GENETICS | 1998年 / 35卷 / 08期
关键词：
asthma; BHR; Fc epsilon RI beta;
D O I：
10.1136/jmg.35.8.680
中图分类号：
Q3 [遗传学];
学科分类号：
071007 ; 090102 ;
摘要：
A study of two DNA polymorphisms (i2 RsaI, E237G) in the gene for the beta subunit of the IgE high affinity receptor (Fc epsilon RI beta) was performed in 168 Italian families with atopic asthmatic children. The prevalence of the E237G allele in the Italian population was 4%, so this polymorphism was unsuitable for this study. The i2 RsaI polymorphism minor allele frequency was 44%, and it had a PIC value of 0.37. Linkage analysis indicated a significant allele sharing in affected sib pairs for bronchial hyper-responsiveness (BHR, p=0.048), but not for allergic asthma. These data indicate an association of bronchial hyper-responsiveness with the Fc epsilon RI beta gene.
引用
收藏
页码：680 / 681
页数：2
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