Construction of Azabicyclo[6.4.0]dodecatrienes Based on Rhodium(I)-Catalyzed Intramolecular [6+2] Cycloaddition between Azetidine, Allene, and Alkynes

被引：2
|
作者：
Yasuda, Shigeo [1 ]
Yokosawa, Haruna [1 ]
Mukai, Chisato [1 ]
机构：
[1] Kanazawa Univ, Div Pharmaceut Sci, Grad Sch Med Sci, Kakuma Machi, Kanazawa, Ishikawa 9201192, Japan
来源：
CHEMICAL & PHARMACEUTICAL BULLETIN | 2016年 / 64卷 / 07期
关键词：
allene; azetidine; 6+2] cycloaddition; bicyclic compound; alkyne; rhodium; BETA-CARBON ELIMINATION; ACTIVATION;
D O I：
10.1248/cpb.c16-00178
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Treatment of the allenylazetidine alkynes with a catalytic amount of [RhCl(CO)dppp](2) (dppp: 1,3-bis(diphenylphosphino)propane) effected the intramolecular hetero-[6+2]-type ring-closing reaction via the C-C bond cleavage of the azetidine ring to produce azabicyclo[6.4.0]dodecatriene derivatives in good to excellent yields. The formation of the oxa analogue could also be achieved.
引用
收藏
页码：805 / 810
页数：6
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