Ruthenium(II)-catalyzed cross-dehydrogenative C-H alkenylations by triazole assistance

被引：46

作者：

Tirler, Carina ^{[1
]}

Ackermann, Lutz ^{[1
]}

机构：

[1] Univ Gottingen, Inst Organ & Biomol Chem, D-37077 Gottingen, Germany

来源：

TETRAHEDRON | 2015年 / 71卷 / 26-27期

基金：

欧洲研究理事会;

关键词：

C-H activation; Mechanism; Olefination; Ruthenium; Triazoles; CATALYZED DIRECT ARYLATIONS; BOND ACTIVATION; CLICK CHEMISTRY; 1,3-DIPOLAR CYCLOADDITIONS; CONJUGATE ADDITION; TERMINAL ALKYNES; FUNCTIONALIZATION; METAL; 1,2,3-TRIAZOLES; CARBOXYLATE;

D O I：

10.1016/j.tet.2015.02.033

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Ruthenium(II) carboxylate complexes allowed for efficient cross-dehydrogenative alkenylations of N-aryl-1,2,3-triazoles. The twofold C-H functionalizations occurred with excellent chemo-, regio-, site- and diastereoselectivities, and ample substrate scope. The versatile ruthenium(II) catalyst proved tolerant of moisture, air, and various electrophilic functional groups. Mechanistic studies were in good agreement with an initial C-H metalation by a cationic ruthenium(II) carboxylate, along with a subsequent migratory insertion of the olefin. (C) 2015 Elsevier Ltd. All rights reserved.

引用

页码：4543 / 4551

页数：9

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