Auto-tandem catalysis:: Synthesis of substituted 11H-indolo [3,2-c]quinolines via palladium-catalyzed intermolecular C-N and intramolecular C-C bond formation

被引：62
|
作者：
Meyers, Caroline [1 ]
Rornbouts, Geert [1 ]
Loones, Kristof T. J. [1 ]
Coelho, Alberto [1 ]
Maes, Bert U. W. [1 ]
机构：
[1] Univ Antwerp, Dept Chem, B-2020 Antwerp, Belgium
来源：
ADVANCED SYNTHESIS & CATALYSIS | 2008年 / 350卷 / 03期
关键词：
amination; C-H activation; malaria; palladium; tandem catalysis;
D O I：
10.1002/adsc.200700328
中图分类号：
O69 [应用化学];
学科分类号：
081704 ;
摘要：
D-Ring substituted 11H-indolo[3,2-c]quinolines (4) have been prepared via auto-tandem consecutive intermolecular Buchwald-Hartwig reaction and intramolecular palladium-catalyzed arylation on 4-chloroquinoline (1) with N-unsubstituted 2-chloroanilines (2). The reported 11H-indolo[3,2-c]quinolines (4) represent the first examples in which tandem catalysis has been used to construct N-unsubstituted carbolines.
引用
收藏
页码：465 / 470
页数：6
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