Synthesis and antibacterial activity of 4-aryl-2-hydroxy-4-oxo-2-butenoic (aroylpyruvic) acids N-(4-guanidylsulfonylphenyl)amides

被引：7
|
作者：
Gein, V. L. [1 ]
Bobrovskaya, O. V. [1 ]
Kovtonogova, I. V. [1 ]
Novikova, V. V. [1 ]
机构：
[1] Perm State Pharmaceut Acad, Perm 614990, Russia
来源：
RUSSIAN JOURNAL OF GENERAL CHEMISTRY | 2015年 / 85卷 / 04期
关键词：
aroylpyruvic acids N-(4-guanidylsulfonylphenyl) amides; 4-aminobenzenesulfonylguanidine; sulgin; antibacterial activity; NUCLEOPHILIC-REAGENTS; OXALYL DERIVATIVES; AROMATIC-AMINES; MECHANISMS; CHEMISTRY; CATALYSIS;
D O I：
10.1134/S1070363215040106
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Reaction of methyl aroylpyruvates with 4-aminobenzolsulfonylguanidine in acetic acid in the presence of anhydrous sodium acetate afforded N-(4-guanidylsulfonylphenyl)amides of 4-aryl-2-hydroxy-4-oxo-2-butenoic acids. Antibacterial activity of the synthesized compounds was studied.
引用
收藏
页码：833 / 836
页数：4
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