Prospects of Neutralizing Nanobodies Against SARS-CoV-2

被引：27
|
作者：
Chen, Fangfang [1 ]
Liu, Zhihong [2 ]
Jiang, Fan [3 ]
机构：
[1] Southern Med Univ, Shenzhen Hosp, Dept Pharm, Shenzhen, Peoples R China
[2] Peking Univ, Sch Chem Biol & Biotechnol, State Key Lab Chem Oncogen, Shenzhen Grad Sch, Shenzhen, Peoples R China
[3] NanoAI Biotech Co Ltd, Huahan Technol Ind Pk, Shenzhen, Peoples R China
来源：
FRONTIERS IN IMMUNOLOGY | 2021年 / 12卷
关键词：
nanobodies (VHH); SARS-CoV-2; phage display; receptor binding domain; neutralizing; SINGLE-DOMAIN ANTIBODY; STRUCTURAL BASIS; FRAGMENTS; POTENT; VHH; IDENTIFICATION; EXPRESSION; SELECTION; PROTECT; DESIGN;
D O I：
10.3389/fimmu.2021.690742
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Since December 2019, the SARS-CoV-2 has erupted on a large scale worldwide and spread rapidly. Passive immunization of antibody-related molecules provides opportunities for prevention and treatment of high-risk patients and children. Nanobodies (Nbs) have many strong physical and chemical properties. They can be atomized, administered by inhalation, and can be directly applied to the infected site, with fast onset, high local drug concentration/high bioavailability, and high patient compliance (no needles). It has very attractive potential in the treatment of respiratory viruses. Rapid and low-cost development of Nbs targeting SARS-CoV-2 can quickly be achieved. Nbs against SARS-CoV-2 mutant strains also can be utilized quickly to prevent the virus from escaping. It provides important technical supports for the treatment of the SARS-CoV-2 and has the potential to become an essential medicine in the toolbox against the SARS-CoV-2.
引用
收藏
页数：8
相关论文
共 50 条
  • [31] A community study of neutralizing antibodies against SARS-CoV-2 in China
    Lv, Yitong
    Huang, Lei
    Wang, Junhu
    He, Hui
    Song, Libo
    He, Jia
    Xu, Lida
    Yu, Changyuan
    Mei, Ying
    Gao, Qi
    [J]. FRONTIERS IN IMMUNOLOGY, 2023, 14
  • [32] Prospects of Coffee Leaf against SARS-CoV-2 Infection
    Wu, Chen-Shiou
    Chiang, Hsiu-Mei
    Chen, Yeh
    Chen, Chung-Yu
    Chen, Hsiao-Fan
    Su, Wen-Chi
    Wang, Wei-Jan
    Chou, Yu-Chi
    Chang, Wei-Chao
    Wang, Shao-Chun
    Hung, Mien-Chie
    [J]. INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES, 2022, 18 (11): : 4677 - 4689
  • [33] Neutralizing Antibodies against SARS-CoV-2 and Other Human Coronaviruses
    Jiang, Shibo
    Hillyer, Christopher
    Du, Lanying
    [J]. TRENDS IN IMMUNOLOGY, 2020, 41 (05) : 355 - 359
  • [34] Potently neutralizing and protective human antibodies against SARS-CoV-2
    Zost, Seth J.
    Gilchuk, Pavlo
    Case, James Brett
    Binshtein, Elad
    Chen, Rita E.
    Nkolola, Joseph P.
    Schafer, Alexandra
    Reidy, Joseph X.
    Trivette, Andrew
    Nargi, Rachel S.
    Sutton, Rachel E.
    Suryadevara, Naveenchandra
    Martinez, David R.
    Williamson, Lauren E.
    Chen, Elaine C.
    Jones, Taylor
    Day, Samuel
    Myers, Luke
    Hassan, Ahmed O.
    Kafai, Natasha M.
    Winkler, Emma S.
    Fox, Julie M.
    Shrihari, Swathi
    Mueller, Benjamin K.
    Meiler, Jens
    Chandrashekar, Abishek
    Mercado, Noe B.
    Steinhardt, James J.
    Ren, Kuishu
    Loo, Yueh-Ming
    Kallewaard, Nicole L.
    McCune, Broc T.
    Keeler, Shamus P.
    Holtzman, Michael J.
    Barouch, Dan H.
    Gralinski, Lisa E.
    Baric, Ralph S.
    Thackray, Larissa B.
    Diamond, Michael S.
    Carnahan, Robert H.
    Crowe, James E., Jr.
    [J]. NATURE, 2020, 584 (7821) : 443 - +
  • [35] Monoclonal neutralizing antibodies against SARS-COV-2 S protein
    Cheng, Lin-Dong
    Li, Ping
    Lin, Yan-Chen
    Hu, Hui-Xiu
    Zhang, Ying
    Li, Hou-Feng
    Huang, Jing
    Tan, Li
    Ma, Ning
    Xia, Deng-Yun
    [J]. AMERICAN JOURNAL OF TRANSLATIONAL RESEARCH, 2024, 16 (02): : 681 - 689
  • [36] Potently neutralizing and protective human antibodies against SARS-CoV-2
    Seth J. Zost
    Pavlo Gilchuk
    James Brett Case
    Elad Binshtein
    Rita E. Chen
    Joseph P. Nkolola
    Alexandra Schäfer
    Joseph X. Reidy
    Andrew Trivette
    Rachel S. Nargi
    Rachel E. Sutton
    Naveenchandra Suryadevara
    David R. Martinez
    Lauren E. Williamson
    Elaine C. Chen
    Taylor Jones
    Samuel Day
    Luke Myers
    Ahmed O. Hassan
    Natasha M. Kafai
    Emma S. Winkler
    Julie M. Fox
    Swathi Shrihari
    Benjamin K. Mueller
    Jens Meiler
    Abishek Chandrashekar
    Noe B. Mercado
    James J. Steinhardt
    Kuishu Ren
    Yueh-Ming Loo
    Nicole L. Kallewaard
    Broc T. McCune
    Shamus P. Keeler
    Michael J. Holtzman
    Dan H. Barouch
    Lisa E. Gralinski
    Ralph S. Baric
    Larissa B. Thackray
    Michael S. Diamond
    Robert H. Carnahan
    James E. Crowe
    [J]. Nature, 2020, 584 : 443 - 449
  • [37] Efficacy of defensins as neutralizing agents against the deadly SARS-CoV-2
    Deepthi, Varughese
    Mohanakumar, Kochupurackal P.
    Rajamma, Usha
    [J]. JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS, 2023, 41 (07): : 2911 - 2925
  • [38] The development of neutralizing antibodies against SARS-CoV-2 and their common features
    Liu, Liu Daisy
    Lian, Chaoyang
    Yeap, Leng-Siew
    Meng, Fei-Long
    [J]. JOURNAL OF MOLECULAR CELL BIOLOGY, 2020, 12 (12) : 980 - 986
  • [39] A cell-free nanobody engineering platform rapidly generates SARS-CoV-2 neutralizing nanobodies
    Xun Chen
    Matteo Gentili
    Nir Hacohen
    Aviv Regev
    [J]. Nature Communications, 12
  • [40] A cell-free nanobody engineering platform rapidly generates SARS-CoV-2 neutralizing nanobodies
    Chen, Xun
    Gentili, Matteo
    Hacohen, Nir
    Regev, Aviv
    [J]. NATURE COMMUNICATIONS, 2021, 12 (01)
12345