Prospects of Neutralizing Nanobodies Against SARS-CoV-2

被引：27
|
作者：
Chen, Fangfang [1 ]
Liu, Zhihong [2 ]
Jiang, Fan [3 ]
机构：
[1] Southern Med Univ, Shenzhen Hosp, Dept Pharm, Shenzhen, Peoples R China
[2] Peking Univ, Sch Chem Biol & Biotechnol, State Key Lab Chem Oncogen, Shenzhen Grad Sch, Shenzhen, Peoples R China
[3] NanoAI Biotech Co Ltd, Huahan Technol Ind Pk, Shenzhen, Peoples R China
来源：
FRONTIERS IN IMMUNOLOGY | 2021年 / 12卷
关键词：
nanobodies (VHH); SARS-CoV-2; phage display; receptor binding domain; neutralizing; SINGLE-DOMAIN ANTIBODY; STRUCTURAL BASIS; FRAGMENTS; POTENT; VHH; IDENTIFICATION; EXPRESSION; SELECTION; PROTECT; DESIGN;
D O I：
10.3389/fimmu.2021.690742
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Since December 2019, the SARS-CoV-2 has erupted on a large scale worldwide and spread rapidly. Passive immunization of antibody-related molecules provides opportunities for prevention and treatment of high-risk patients and children. Nanobodies (Nbs) have many strong physical and chemical properties. They can be atomized, administered by inhalation, and can be directly applied to the infected site, with fast onset, high local drug concentration/high bioavailability, and high patient compliance (no needles). It has very attractive potential in the treatment of respiratory viruses. Rapid and low-cost development of Nbs targeting SARS-CoV-2 can quickly be achieved. Nbs against SARS-CoV-2 mutant strains also can be utilized quickly to prevent the virus from escaping. It provides important technical supports for the treatment of the SARS-CoV-2 and has the potential to become an essential medicine in the toolbox against the SARS-CoV-2.
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页数：8
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