Melanocortin-4 receptor regulation of pain

被引：17

作者：

Li, Zhi-Xiao ^{[1
]}

Liu, Bao-Wen ^{[1
]}

He, Zhi-Gang ^{[1
]}

Xiang, Hong-Bing ^{[1
]}

机构：

[1] Huazhong Univ Sci & Technol, Tongji Med Coll, Tongji Hosp, Dept Anesthesiol & Pain Med, Wuhan 430030, Hubei, Peoples R China

来源：

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE | 2017年 / 1863卷 / 10期

基金：

中国国家自然科学基金;

关键词：

Melanocortin receptor; Nervous system; Pain; ROSTRAL VENTROMEDIAL MEDULLA; PEDUNCULOPONTINE TEGMENTAL NUCLEUS; CHRONIC CONSTRICTION INJURY; ANTERIOR CINGULATE CORTEX; SUDDEN UNEXPECTED DEATH; DEEP BRAIN-STIMULATION; BODY-WEIGHT REGULATION; PERIAQUEDUCTAL GRAY; CUNEIFORM NUCLEUS; NEUROPATHIC PAIN;

D O I：

10.1016/j.bbadis.2017.05.021

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

An increasingly high occurrence of chronic pain in patients highlights the importance of fundamental research. The melanocortin-4 receptor (MC4R) regulation of pain has attracted much attention in recent years due to its high expression in the mammalian brain regions related to nociception and pain. This review is devoted to anatomic distribution of MC4R in the brain and interaction between MC4R and other pathways for pain modulation. The experimental evidence available at present had expanded our understanding of melanocortin-4 receptor regulation of pain. This article is part of a Special Issue entitled: Melanocortin Receptors - edited by YaXiong Tao.

引用

页码：2515 / 2522

页数：8

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