Tumor-targeting with novel pyridyl 6-substituted pyrrolo[2,3-d]pyrimidine antifolates via cellular uptake by folate receptor (FR) α and the proton-coupled folate transporter (PCFT) and inhibition of de novo purine nucleotide biosynthesis

被引:0
|
作者
Cherian, Christina [1 ]
Wang, Lei [2 ]
Wallace, Adrianne [1 ]
Orr, Steven [1 ]
Hou, Zhanjun [1 ]
Gangjee, Aleem [2 ]
Matherly, Larry H. [1 ]
机构
[1] Barbara Ann Karmanos Canc Inst, Detroit, MI USA
[2] Duquesne Univ, Pittsburgh, PA 15219 USA
关键词
D O I
10.1158/1538-7445.AM2014-2706
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
2706
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收藏
页数:1
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