The Landscape of Regulatory Noncoding RNAs in Ewing's Sarcoma

被引:9
|
作者
Barrett, Connor [1 ]
Budhiraja, Anuj [1 ]
Parashar, Vijay [1 ]
Batish, Mona [1 ]
机构
[1] Univ Delaware, Dept Med & Mol Sci, Newark, DE 19716 USA
关键词
Ewing's sarcoma; noncoding RNAs; microRNAs; long noncoding RNAs; regulatory RNAs; tumor progression; epigenetics; biomarkers; therapeutic targets; POSITIVE FEEDBACK LOOP; MIRNA EXPRESSION; CELL-PROLIFERATION; EWS/FLI-1; FUSION; CIRCULAR RNAS; EMERGING ROLE; CANCER; SURVIVAL; PROGRESSION; IDENTIFICATION;
D O I
10.3390/biomedicines9080933
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Ewing's sarcoma (ES) is a pediatric sarcoma caused by a chromosomal translocation. Unlike in most cancers, the genomes of ES patients are very stable. The translocation product of the EWS-FLI1 fusion is most often the predominant genetic driver of oncogenesis, and it is pertinent to explore the role of epigenetic alterations in the onset and progression of ES. Several types of noncoding RNAs, primarily microRNAs and long noncoding RNAs, are key epigenetic regulators that have been shown to play critical roles in various cancers. The functions of these epigenetic regulators are just beginning to be appreciated in ES. Here, we performed a comprehensive literature review to identify these noncoding RNAs. We identified clinically relevant tumor suppressor microRNAs, tumor promoter microRNAs and long noncoding RNAs. We then explored the known interplay between different classes of noncoding RNAs and described the currently unmet need for expanding the noncoding RNA repertoire of ES. We concluded the review with a discussion of epigenetic regulation of ES via regulatory noncoding RNAs. These noncoding RNAs provide new avenues of exploration to develop better therapeutics and identify novel biomarkers.
引用
收藏
页数:15
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