Carvacrol Alleviates Prostate Cancer Cell Proliferation, Migration, and Invasion through Regulation of PI3K/Akt and MAPK Signaling Pathways

被引：62
|
作者：
Luo, Yun [1 ]
Wu, Jie-Ying [1 ]
Lu, Min-Hua [1 ]
Shi, Zhi [2 ,3 ]
Na, Ning [4 ]
Di, Jin-Ming [1 ]
机构：
[1] Sun Yat Sen Univ, Affiliated Hosp 3, Dept Urol, Guangzhou 510630, Guangdong, Peoples R China
[2] Jinan Univ, Coll Life Sci & Technol, Natl Engn Res Ctr Genet Med, Dept Cell Biol, Guangzhou 510632, Guangdong, Peoples R China
[3] Jinan Univ, Coll Life Sci & Technol, Guangdong Prov Key Lab Bioengn Med, Inst Biomed,Natl Engn Res Ctr Genet Med, Guangzhou 510632, Guangdong, Peoples R China
[4] Sun Yat Sen Univ, Affiliated Hosp 3, Dept Kidney Transplantat, Guangzhou 510630, Guangdong, Peoples R China
来源：
OXIDATIVE MEDICINE AND CELLULAR LONGEVITY | 2016年 / 2016卷
基金：
高等学校博士学科点专项科研基金; 中国国家自然科学基金;
关键词：
IN-VITRO; TRP-PLIK; CHANNELS; INHIBITION; ACTIVATION; KINASE; GROWTH; ABCB1;
D O I：
10.1155/2016/1469693
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
TRPM7 is a potential therapeutic target for treatment of prostate cancer. In this study, we investigated the effects of nonselective TRPM7 inhibitor carvacrol on cell proliferation, migration, and invasion of prostate cancer PC-3 and DU145 cells. Our results showed that carvacrol blocked TRPM7-like currents in PC-3 and DU145 cells and reduced their proliferation, migration, and invasion. Moreover, carvacrol treatment significantly decreased MMP-2, p-Akt, and p-ERK1/2 protein expression and inhibited F-actin reorganization. Furthermore, consistently, TRPM7 knockdown reduced prostate cancer cell proliferation, migration, and invasion as well. Our study suggests that carvacrol may have therapeutic potential for the treatment of prostate cancer through its inhibition of TRPM7 channels and suppression of PI3K/Akt and MAPK signaling pathways.
引用
收藏
页数：11
相关论文
共 50 条
  • [41] Geraniin inhibits migration and invasion of human osteosarcoma cancer cells through regulation of PI3K/Akt and ERK1/2 signaling pathways
    Wang, Yanmao
    Wan, Daqian
    Zhou, Runhua
    Zhong, Wanrun
    Lu, Shengdi
    Chai, Yimin
    ANTI-CANCER DRUGS, 2017, 28 (09) : 959 - 966
  • [42] Silibinin inhibits cell invasion through inactivation of both PI3K-Akt and MAPK signaling pathways
    Chen, PN
    Hsieh, YS
    Chiou, HL
    Chu, SC
    CHEMICO-BIOLOGICAL INTERACTIONS, 2005, 156 (2-3) : 141 - 150
  • [43] TIPE2 Overexpression Suppresses the Proliferation; Migration, and Invasion in Prostate Cancer Cells by Inhibiting PI3K/Akt Signaling Pathway
    Lu, Qiang
    Liu, Zhe
    Li, Zhuo
    Chen, Jia
    Liao, Zhi
    Wu, Wan-rui
    Li, Yuan-wei
    ONCOLOGY RESEARCH, 2016, 24 (05) : 305 - 313
  • [44] Lipopolysaccharide promotes cancer cell migration and invasion through METTL3/PI3K/AKT signaling in human cholangiocarcinoma
    Ke, Jing
    Zhang, Chang-jiang
    Wang, Lian-zi
    Xie, Feng-shuo
    Wu, Hong-Yu
    Li, Tao
    Bian, Cong-Wen
    Wu, Ruo-Lin
    HELIYON, 2024, 10 (08)
  • [45] LETM1 Promotes Gastric Cancer Cell Proliferation, Migration, and Invasion via the PI3K/Akt Signaling Pathway
    Zhang, Yunfeng
    Chen, Lele
    Cao, Yifan
    Chen, Si
    Xu, Chao
    Xing, Jun
    Zhang, Kaiguang
    JOURNAL OF GASTRIC CANCER, 2020, 20 (02) : 139 - 151
  • [46] Plantamajoside Reduces Gastric Cancer Cell Migration and Invasion by Inhibiting PI3K/AKT and ERK Pathways
    Tang, Chenglu
    Wang, Yuanyuan
    Huang, Jing
    Lv, Xiaohong
    CURRENT TOPICS IN NUTRACEUTICAL RESEARCH, 2023, 21 (02) : 175 - 181
  • [47] Protein O-fucosyltransferase 1 promotes trophoblast cell proliferation through activation of MAPK and PI3K/Akt signaling pathways
    Liu, Chang
    Liang, Xiaohua
    Wang, Jiao
    Zheng, Qin
    Zhao, Yue
    Khan, Muhammad Noman
    Liu, Shuai
    Yan, Qiu
    BIOMEDICINE & PHARMACOTHERAPY, 2017, 88 : 95 - 101
  • [48] The Role of PI3K/AKT and MAPK Signaling Pathways in Erythropoietin Signalization
    Tothova, Zuzana
    Semelakova, Martina
    Solarova, Zuzana
    Tomc, Jana
    Debeljak, Natasa
    Solar, Peter
    INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2021, 22 (14)
  • [49] SOSTDC1 inhibits follicular thyroid cancer cell proliferation, migration, and EMT via suppressing PI3K/Akt and MAPK/Erk signaling pathways
    Zhou, Qinyi
    Chen, Jun
    Feng, Jialin
    Xu, Yanan
    Zheng, Wenjie
    Wang, Jiadong
    MOLECULAR AND CELLULAR BIOCHEMISTRY, 2017, 435 (1-2) : 87 - 95
  • [50] SOSTDC1 inhibits follicular thyroid cancer cell proliferation, migration, and EMT via suppressing PI3K/Akt and MAPK/Erk signaling pathways
    Qinyi Zhou
    Jun Chen
    Jialin Feng
    Yanan Xu
    Wenjie Zheng
    Jiadong Wang
    Molecular and Cellular Biochemistry, 2017, 435 : 87 - 95
12345