Oligosaccharide synthesis on a soluble, hyperbranched polymer support via thioglycoside activation

被引：11
|
作者：
Kantchev, EAB [1 ]
Bader, SJ [1 ]
Parquette, JR [1 ]
机构：
[1] Ohio State Univ, Dept Chem, Columbus, OH 43210 USA
来源：
TETRAHEDRON | 2005年 / 61卷 / 35期
关键词：
carbohydrates; glycosylations; polymers; dendrimers; solid-phase;
D O I：
10.1016/j.tet.2005.06.101
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
The synthesis of linear and branched di-, tri- and tetramannosides on a commercially available hyperbranched polyester as a soluble, high loading support is described. Gil/cosylation products were isolated in 26-63% yield as mixtures of anomers after total hydrolytic degradation of the polymer. All polymer-bound intermediates were purified through simple extraction or precipitation. Solution phase NMR and MALDI-TOF were used to monitor the progress of the reaction directly on the hyperbranched polymer support. (c) 2005 Elsevier Ltd. All rights reserved.
引用
收藏
页码：8329 / 8338
页数：10
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