Oligosaccharide synthesis on a soluble, hyperbranched polymer support via thioglycoside activation

被引：11

作者：

Kantchev, EAB ^{[1
]}

Bader, SJ ^{[1
]}

Parquette, JR ^{[1
]}

机构：

[1] Ohio State Univ, Dept Chem, Columbus, OH 43210 USA

来源：

TETRAHEDRON | 2005年 / 61卷 / 35期

关键词：

carbohydrates; glycosylations; polymers; dendrimers; solid-phase;

D O I：

10.1016/j.tet.2005.06.101

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The synthesis of linear and branched di-, tri- and tetramannosides on a commercially available hyperbranched polyester as a soluble, high loading support is described. Gil/cosylation products were isolated in 26-63% yield as mixtures of anomers after total hydrolytic degradation of the polymer. All polymer-bound intermediates were purified through simple extraction or precipitation. Solution phase NMR and MALDI-TOF were used to monitor the progress of the reaction directly on the hyperbranched polymer support. (c) 2005 Elsevier Ltd. All rights reserved.

引用

页码：8329 / 8338

页数：10

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