Menstrual Toxic Shock Syndrome: A French Nationwide Multicenter Retrospective Study

被引：6

作者：

Contou, Damien ^{[1
]}

Colin, Gwenhael ^{[2
]}

Travert, Brendan ^{[3
]}

Jochmans, Sebastien ^{[4
,5
]}

Conrad, Marie ^{[6
]}

Lascarrou, Jean-Baptiste ^{[7
]}

Painvin, Benoit ^{[8
]}

Ferre, Alexis ^{[9
]}

Schnell, David ^{[10
]}

La Combe, Beatrice ^{[11
]}

Coudroy, Remi ^{[12
,13
]}

Ehrmann, Stephan ^{[14
]}

Rambaud, Jerome ^{[15
]}

Wiedemann, Arnaud ^{[16
]}

Asfar, Pierre ^{[17
]}

Kalfon, Pierre ^{[18
]}

Guerot, Emmanuel ^{[19
]}

Preau, Sebastien ^{[20
]}

Argaud, Laurent ^{[21
]}

Daviet, Florence ^{[22
]}

Dellamonica, Jean ^{[23
]}

Dupont, Audrey ^{[24
]}

Fartoukh, Muriel ^{[25
]}

Kamel, Toufik ^{[26
]}

Beduneau, Gaetan ^{[27
]}

Canoui-Poitrine, Florence ^{[28
]}

Boutin, Emmanuelle ^{[28
]}

Lina, Gerard ^{[29
]}

Dessap, Armand Mekontso ^{[30
]}

Tristan, Anne ^{[29
]}

de Prost, Nicolas ^{[30
]}

机构：

[1] Ctr Hosp Victor Dupouy, Serv Reanimat Polyvalente, 69 Rue Lieutenant Colonel Prudhon, F-95100 Argenteuil, France

[2] Ctr Hosp Dept Vendee, Serv Med Intens Reanimat, Blvd Stephane Moreau, La Roche Sur Yon, France

[3] Ctr Hosp Univ Nantes, Serv Reanimat Pediat, Nantes, France

[4] Grp Hosp Sud Ile de France, Serv Med Intens Reanimat, Melun, France

[5] Hop Melun Senart, Melun, France

[6] Ctr Hosp Univ Nancy, Serv Reanimat, Nancy, France

[7] Ctr Hosp Univ Nantes, Serv Med Intens & Reanimat, Nantes, France

[8] Ctr Hosp Univ Rennes, Serv Malad Infect & Reanimat Med, Rennes, France

[9] Ctr Hosp Andre Mignot Versailles, Serv Reanimat Med Chirurg, Le Chesnay, France

[10] Ctr Hosp Angouleme, Serv Med Reanimat Polyvalente, Angouleme, France

[11] Hop Scorff Grp Hosp Bretagne Sud Lorient, Serv Reanimat Med Chirurg, Lorient, France

[12] Ctr Hosp Univ Poitiers, Serv Med Intens & Reanimat, Poitiers, France

[13] Univ Poitiers, ALIVE Grp, INSERM CIC1402, Poitiers, France

[14] Univ Tours, INSERM U1100, Ctr Etud Pathol Resp, CRICS TriggerSEP,CHRU Tours,CIC 1415,Serv Med Int, Tours, France

[15] Hop Trousseau, AP HP, Serv Reanimat Pediat, Paris, France

[16] CHRU, INSERM U1256 N GERE & Reanimat Pediat Specialisee, Vandoeuvre Les Nancy, France

[17] Ctr Hosp Univ Angers, Dept Med Intens Reanimat, Angers, France

[18] Ctr Hosp Chartres, Serv Reanimat, Le Coudray, France

[19] Hop Europeen Georges Pompidou, AP HP, Serv Med Intens Reanimat, Paris, France

[20] Ctr Hosp Univ Lille, Serv Reanimat, Lille, France

[21] Hop Edouard Herriot, Serv Med Intens Reanimat, Lyon, France

[22] Aix Marseille Univ, Hop Nord, Assistance Publ Hop Marseille, Serv Med Intens Reanimat, Chemin Bourrely, Marseille, France

[23] UR2CA Univ Cote Azur, Ctr Hosp Univ Nice, Serv Med Intens Reanimat, Nice, France

[24] Ctr Hosp Univ Nice, Serv Reanimat Pediat, Nice, France

[25] Sorbonne Univ, Ctr Hosp Univ Tenon AP HP, AP HP, Serv Med Intens Reanimat, Paris, France

[26] Ctr Hosp Reg Orleans, Serv Med Intens Reanimat, Hop La Source, Orleans, France

[27] Univ Normandie, Ctr Hosp Univ Rouen, Serv Reanimat Med, UNIROUEN,EA3830, Rouen, France

[28] Hop Henri Mondor, AP HP, Serv Sante Publ, Creteil, France

[29] Hosp Civils Lyon, Ctr Natl Reference Staphylocoques, Inst Agent Infect, Hop Croix Rousse, Lyon, France

[30] Ctr Hosp Univ Henri Mondor, Assistance Publ Hop Paris, Serv Med Intens Reanimat, Grp Rech CARMAS, Creteil, France

来源：

CLINICAL INFECTIOUS DISEASES | 2022年 / 74卷 / 02期

关键词：

menstrual toxic shock syndrome; menstruation; sepsis; Staphylococcus; aureus; ICU; tampon; STAPHYLOCOCCUS-AUREUS; TAMPON USE; GENES; SCORE;

D O I：

10.1093/cid/ciab378

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Background Studies describing the clinical features and short-term prognosis of patients admitted to the intensive care unit (ICU) for menstrual toxic shock syndrome (m-TSS) are lacking. Methods This was a multicenter retrospective cohort study of patients with a clinical diagnosis of m-TSS admitted between 1 January 2005 and 31 December 2020 in 43 French pediatric (n = 7) or adult (n = 36) ICUs. The aim of the study was to describe the clinical features and short-term prognosis, as well as to assess the 2011 Centers for Disease and Control (CDC) diagnostic criteria, in critically ill patients with m-TSS. Results In total, 102 patients with m-TSS (median age, 18 years; interquartile range, 16-24 years) were admitted to 1 of the participating ICUs. All blood cultures (n = 102) were sterile. Methicillin-sensitive Staphylococcus aureus grew from 92 of 96 vaginal samples. Screening for superantigenic toxin gene sequences was performed for 76 of the 92 vaginal samples positive for S. aureus (83%), and toxic shock syndrome toxin 1 was isolated from 66 strains (87%). At ICU admission, no patient met the 2011 CDC criteria for confirmed m-TSS, and only 53 (52%) fulfilled the criteria for probable m-TSS. Eighty-one patients (79%) were treated with antitoxin antibiotic therapy, and 8 (8%) received intravenous immunoglobulins. Eighty-six (84%) patients required vasopressors, and 21 (21%) tracheal intubation. No patient required limb amputation or died in the ICU. Conclusions In this large multicenter series of patients included in ICUs for m-TSS, none died or required limb amputation. The CDC criteria should not be used for the clinical diagnosis of m-TSS at ICU admission. None of the patients with menstrual toxic shock syndrome required limb amputation or died despite a high rate of vasopressor support and invasive mechanical ventilation. Centers for Disease Control and Prevention criteria should not be used for clinical diagnosis at intensive care unit admission.

引用

页码：246 / 253

页数：8

共 50 条

[21] MENSTRUAL TOXIC SHOCK SYNDROMES
BERTSCHAT, FL
LUCKBERTSCHAT, G
HOFFMANN, HG
ALEXANDER, M
MEDIZINISCHE WELT, 1987, 38 (29): : 1013 - 1015
[22] Nationwide study of mortality and survival in pregnancy-related streptococcal toxic shock syndrome
Hayata, Eijiro
Nakata, Masahiko
Hasegawa, Junichi
Tanaka, Hiroaki
Murakoshi, Takeshi
Mitsuda, Nobuaki
Sekizawa, Akihiko
Ikeda, Tomoaki
Ishiwata, Isamu
JOURNAL OF OBSTETRICS AND GYNAECOLOGY RESEARCH, 2021, 47 (03) : 928 - 934
[23] Inflammatory Arthritis in Patients with Myelodysplastic Syndrome: French Multicenter Retrospective Study
Mekinian, Arsene
Decaux, Olivier
Falgarone, Geraldine
Braun, Thorsten, Sr.
Toussirot, Eric
Raffray, Loic
Gombert, Bruno
de Wazieres, Bruno
Buchdaul, Anne Laure
Ziza, Jean-Marc
Launay, David
Denis, Guillaume
Madaule, Serge
Fenaux, Pierre
Fain, Olivier
ARTHRITIS AND RHEUMATISM, 2012, 64 (10): : S83 - S84
[24] One in five mortality in non-menstrual toxic shock syndrome versus no mortality in menstrual cases in a balanced French series of 55 cases
Descloux, E.
Perpoint, T.
Ferry, T.
Lina, G.
Bes, M.
Vandenesch, F.
Mohammedi, I.
Etienne, J.
EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES, 2008, 27 (01) : 37 - 43
[25] One in five mortality in non-menstrual toxic shock syndrome versus no mortality in menstrual cases in a balanced French series of 55 cases
E. Descloux
T. Perpoint
T. Ferry
G. Lina
M. Bes
F. Vandenesch
I. Mohammedi
J. Etienne
European Journal of Clinical Microbiology & Infectious Diseases, 2008, 27 : 37 - 43
[26] NON-MENSTRUAL TOXIC SHOCK SYNDROME - A REVIEW OF 130 CASES
REINGOLD, AL
HARGRETT, NT
DAN, BB
SHANDS, KN
STRICKLAND, BY
BROOME, CV
ANNALS OF INTERNAL MEDICINE, 1982, 96 (06) : 871 - 874
[27] MENSTRUAL TOXIC SHOCK SYNDROME IN A 17-YEAR-OLD GIRL
DEUPMANN, M
KUNSTMANN, G
MAUFF, G
BERGDOLL, M
MONATSSCHRIFT KINDERHEILKUNDE, 1985, 133 (04) : 238 - 240
[28] A case of non-menstrual staphylococal toxic shock syndrome.
Arora, S
JOURNAL OF GENERAL INTERNAL MEDICINE, 2004, 19 : 24 - 25
[29] Immunoglobulin therapy in non-menstrual streptococcal toxic shock syndrome
Murthy, BVS
Nelson, RA
Mannion, PT
ANAESTHESIA AND INTENSIVE CARE, 2003, 31 (03) : 320 - 323
[30] TOXIC SHOCK SYNDROME OCCURRING IN THE LUTEAL PHASE OF THE MENSTRUAL-CYCLE
PODLAS, J
BARBIERI, RL
SALZMAN, R
WOODSON, J
FULLER, AF
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY, 1981, 141 (02) : 225 - 227

← 1 2 3 4 5 →