QTc prolongation and treatment of multidrug-resistant tuberculosis

被引：48

作者：

Harausz, E. ^{[1
]}

Cox, H. ^{[2
,3
]}

Rich, M. ^{[4
]}

Mitnick, C. D. ^{[5
]}

Zimetbaum, P. ^{[6
]}

Furin, J. ^{[1
]}

机构：

[1] Case Western Reserve Univ, TB Res Unit, Cleveland, OH 44106 USA

[2] Univ Cape Town, Div Med Microbiol, ZA-7700 Rondebosch, South Africa

[3] Univ Cape Town, Inst Infect Dis & Mol Med, ZA-7700 Rondebosch, South Africa

[4] Brigham & Womens Hosp, Div Global Hlth Equ, Boston, MA 02115 USA

[5] Harvard Univ, Sch Med, Dept Global Hlth & Social Med, Boston, MA USA

[6] Beth Israel Deaconess Med Ctr, Div Cardiol, Boston, MA 02215 USA

来源：

INTERNATIONAL JOURNAL OF TUBERCULOSIS AND LUNG DISEASE | 2015年 / 19卷 / 04期

关键词：

MDR-TB; ECG; QTc; TORSADES-DE-POINTES; EARLY BACTERICIDAL ACTIVITY; INTERVAL PROLONGATION; DIARYLQUINOLINE TMC207; DELAMANID OPC-67683; DRUG; SAFETY; RISK; PHARMACOKINETICS; FLUOROQUINOLONES;

D O I：

10.5588/ijtld.14.0335

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

Electrocardiographic (ECG) monitoring is recommended for some of the new and re-purposed drugs used in the treatment of multidrug-resistant tuberculosis (MDR-TB), as these drugs have been shown to prolong the QTc interval. ECG monitoring is relatively new in the management of TB patients, and has several implications for programs and providers. This review discusses what is known about QTc prolongation and the medications currently being studied or used to treat MDR-TB, and discusses strategies for managing QTc prolongation in the context of treating such a serious infectious disease. It also reviews some major implications of ECG monitoring in the field, including interpretation of ECGs and QTc intervals, management of patients with prolonged QTc intervals, and contextualizing the risk of QTc prolongation for patients being treated for MDR-TB.

引用

页码：385 / 391

页数：7

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